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CLC number: R394

On-line Access: 2019-03-01

Received: 2018-05-11

Revision Accepted: 2018-12-23

Crosschecked: 2019-01-10

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Bo-feng Zhu

https://orcid.org/0000-0001-7877-7387

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.3 P.287-290

http://doi.org/10.1631/jzus.B1800279


Genetic distribution and forensic evaluation of multiplex autosomal short tandem repeats in the Chinese Xinjiang Mongolian group


Author(s):  Yuan-yuan Wei, Xiao-ye Jin, Qiong Lan, Wei Cui, Chong Chen, Ting-ting Kong, Yu-xin Guo, Jian-gang Chen, Bo-feng Zhu

Affiliation(s):  Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China; more

Corresponding email(s):   chenjiangang@cifs.gov.cn, zhubofeng7372@126.com

Key Words:  Xinjiang Mongolian group, Short tandem repeats (STRs), Forensic applications


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Yuan-yuan Wei, Xiao-ye Jin, Qiong Lan, Wei Cui, Chong Chen, Ting-ting Kong, Yu-xin Guo, Jian-gang Chen, Bo-feng Zhu. Genetic distribution and forensic evaluation of multiplex autosomal short tandem repeats in the Chinese Xinjiang Mongolian group[J]. Journal of Zhejiang University Science B, 2019, 20(3): 287-290.

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author="Yuan-yuan Wei, Xiao-ye Jin, Qiong Lan, Wei Cui, Chong Chen, Ting-ting Kong, Yu-xin Guo, Jian-gang Chen, Bo-feng Zhu",
journal="Journal of Zhejiang University Science B",
volume="20",
number="3",
pages="287-290",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1800279"
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Abstract: 
To further enrich the genetic data of the Chinese xinjiang Mongolian group, the genetic distribution and forensic parameters of 19 autosomal short tandem repeats (STRs) were investigated. Altogether, 249 alleles were observed in these 19 STRs. The mean values of the polymorphism information content (PIC), match probability (MP), discrimination power (DP), and probability of exclusion (PE) for these 19 STRs were 0.7775, 0.0699, 0.9301, and 0.6085, respectively. Additionally, the cumulative DP and PE values obtained in the Mongolian group were 0.999 999 999 999 999 999 999 995 67 and 0.999 999 992 163, respectively. Furthermore, population genetic analysis of the Mongolian group and 20 published populations was conducted based on the population data of 15 overlapping STRs. Genetic distances indicated that the Mongolian group had closer genetic similarities with the Uyghur, Xibe, and other Chinese populations rather than the other continental populations. Multidimensional scaling analysis further revealed that the Mongolian group possessed similar genetic distributions as most Chinese populations. To sum it all up, these STRs could be used as an extremely efficient tool for forensic applications in the xinjiang Mongolian group.

常染色体19个STR位点在新疆蒙古族中的遗传多态性和法医学价值研究

目的:分析常染色体19个短串联重复序列(STR)位点在新疆蒙古族群体中的遗传多态性分布,为其法医学应用提供数据支持.
创新点:丰富了新疆蒙古族群体的常染色体STR遗传数据.
方法:从新疆地区采集1133个无血缘关系的蒙古族健康个体,应用一个包含常染色体19个STR位点的复合扩增体系对这些样本进行基因分型检测.同时,基于15个共有的STR位点,采用多维尺度分析、遗传距离(DA)和遗传分化系数(FST)的方法探讨了新疆蒙古族群体和既往报道的20个群体间的群体遗传关系.
结论:研究的19个STR位点在新疆蒙古族群体中表现出高度的多态性,获得的累积非父排除概率和累计个体识别率分别为0.999 999 992 163和0.999 999 999 999 999 999 999 995 67,表明这19个STR位点可很好地应用于新疆蒙古族群体的个体识别和亲缘关系鉴识研究.群体遗传分析的结果显示:相比其他洲际群体,新疆蒙古族群体和维吾尔族、锡伯族以及其他中国群体具有更近的遗传距离.

关键词:新疆蒙古族;短串联重复序列(STR);法医学

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Reference

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[11]List of electronic supplementary materials

[12]Data S1 Materials and methods

[13]Fig. S1 Reverse triangular plot of the Lewontin’s D' values for 19 pairwise STRs in the Mongolian group

[14]Table S1 Populations used as compared populations and their corresponding references

[15]Table S2 Allele frequencies and forensic statistical parameters of 19 STRs in the Mongolian group

[16]Table S3 Genetic distances (DA) among 21 populations based on the allele frequencies of 15 STRs

[17]Table S4 Fixation index (FST) and their corresponding P-values of the pairwise populations

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