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Received: 2019-03-31

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Crosschecked: 2019-04-23

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Jun Chen


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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.6 P.457-466


p53 and its isoforms in DNA double-stranded break repair

Author(s):  Yu-Xi Zhang, Wen-Ya Pan, Jun Chen

Affiliation(s):  MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   chenjun2009@zju.edu.cn

Key Words:  p53, p53 isoform, DNA double-stranded break repair, Cell death

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Yu-Xi Zhang, Wen-Ya Pan, Jun Chen. p53 and its isoforms in DNA double-stranded break repair[J]. Journal of Zhejiang University Science B, 2019, 20(6): 457-466.

@article{title="p53 and its isoforms in DNA double-stranded break repair",
author="Yu-Xi Zhang, Wen-Ya Pan, Jun Chen",
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publisher="Zhejiang University Press & Springer",

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%T p53 and its isoforms in DNA double-stranded break repair
%A Yu-Xi Zhang
%A Wen-Ya Pan
%A Jun Chen
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900167

T1 - p53 and its isoforms in DNA double-stranded break repair
A1 - Yu-Xi Zhang
A1 - Wen-Ya Pan
A1 - Jun Chen
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 6
SP - 457
EP - 466
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900167

DNA double-stranded break (DSB) is one of the most catastrophic damages of genotoxic insult. Inappropriate repair of DNA DSBs results in the loss of genetic information, mutation, and the generation of harmful genomic rearrangements, which predisposes an organism to immunodeficiency, neurological damage, and cancer. The tumor repressor p53 plays a key role in DNA damage response, and has been found to be mutated in 50% of human cancer. p53, p63, and p73 are three members of the p53 gene family. Recent discoveries have shown that human p53 gene encodes at least 12 isoforms. Different p53 members and isoforms play various roles in orchestrating DNA damage response to maintain genomic integrity. This review briefly explores the functions of p53 and its isoforms in DNA DSB repair.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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