CLC number: R739.65
On-line Access: 2019-08-05
Received: 2019-04-03
Revision Accepted: 2019-06-16
Crosschecked: 2019-07-09
Cited: 0
Clicked: 3958
Han-Ying Wang, Hui Yuan, Jing-Hui Liu, Bei-Lei Wang, Kai-Lun Xu, Pu Huang, Zhi-Hong Lin, Li-Hong Xu. Comparative analysis of a panel of biomarkers related to protein phosphatase 2A between laryngeal squamous cell carcinoma tissues and adjacent normal tissues[J]. Journal of Zhejiang University Science B, 2019, 20(9): 776-780.
@article{title="Comparative analysis of a panel of biomarkers related to protein phosphatase 2A between laryngeal squamous cell carcinoma tissues and adjacent normal tissues",
author="Han-Ying Wang, Hui Yuan, Jing-Hui Liu, Bei-Lei Wang, Kai-Lun Xu, Pu Huang, Zhi-Hong Lin, Li-Hong Xu",
journal="Journal of Zhejiang University Science B",
volume="20",
number="9",
pages="776-780",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900179"
}
%0 Journal Article
%T Comparative analysis of a panel of biomarkers related to protein phosphatase 2A between laryngeal squamous cell carcinoma tissues and adjacent normal tissues
%A Han-Ying Wang
%A Hui Yuan
%A Jing-Hui Liu
%A Bei-Lei Wang
%A Kai-Lun Xu
%A Pu Huang
%A Zhi-Hong Lin
%A Li-Hong Xu
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 9
%P 776-780
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900179
TY - JOUR
T1 - Comparative analysis of a panel of biomarkers related to protein phosphatase 2A between laryngeal squamous cell carcinoma tissues and adjacent normal tissues
A1 - Han-Ying Wang
A1 - Hui Yuan
A1 - Jing-Hui Liu
A1 - Bei-Lei Wang
A1 - Kai-Lun Xu
A1 - Pu Huang
A1 - Zhi-Hong Lin
A1 - Li-Hong Xu
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 9
SP - 776
EP - 780
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900179
Abstract: laryngeal squamous cell carcinoma (LSCC) is the most common type of head and neck squamous cell carcinoma (HNSCC) worldwide. protein phosphatase 2A (PP2A) dysfunction has been widely reported in a broad range of malignancies due to its distinctive role in miscellaneous cellular processes. However, it is poorly understood whether aberrant alterations of PP2A are involved in the network of oncogenic events in LSCC. Here, we detected a panel of PP2A-associated proteins using western blot in both laryngeal squamous cell carcinoma tissues and paired adjacent normal tissues from patients (Data S1). We found that phospho-PP2A/C (Y307), α4, cancerous inhibitor of protein phosphatase 2A (CIP2A), Akt, ezrin, phospho-ezrin (T567), 14-3-3, and focal adhesion kinase (FAK) showed increased expression levels in carcinoma tissues relative to normal tissues, while phospho-Akt (T308) showed decreased levels. Our study, thus, provides a rationale for targeting PP2A to develop novel therapies and proposes a combination of interrelated biomarkers for the diagnostic evaluation and prognosis prediction in LSCC.
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[16]List of electronic supplementary materials
[17]Data S1 Materials and methods
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