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CLC number: R739.81

On-line Access: 2012-02-29

Received: 2011-03-12

Revision Accepted: 2011-12-27

Crosschecked: 2011-12-14

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.3 P.168-175

http://doi.org/10.1631/jzus.B1100077


Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma


Author(s):  Ying Qiu, Zhu-ling Wang, Shu-qing Jin, Yu-fei Pu, Satoru Toyosawa, Katsuyuki Aozasa, Eiichi Morii

Affiliation(s):  Department of Pathology, School of Medicine, Tsinghua University, Beijng 100084, China; more

Corresponding email(s):   yingqiu2009@gmail.com

Key Words:  Gingival squamous cell carcinoma, Pre-B-cell leukemia transcription factor 2 (PBX2), Prognosis


Ying Qiu, Zhu-ling Wang, Shu-qing Jin, Yu-fei Pu, Satoru Toyosawa, Katsuyuki Aozasa, Eiichi Morii. Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma[J]. Journal of Zhejiang University Science B, 2012, 13(3): 168-175.

@article{title="Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma",
author="Ying Qiu, Zhu-ling Wang, Shu-qing Jin, Yu-fei Pu, Satoru Toyosawa, Katsuyuki Aozasa, Eiichi Morii",
journal="Journal of Zhejiang University Science B",
volume="13",
number="3",
pages="168-175",
year="2012",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100077"
}

%0 Journal Article
%T Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma
%A Ying Qiu
%A Zhu-ling Wang
%A Shu-qing Jin
%A Yu-fei Pu
%A Satoru Toyosawa
%A Katsuyuki Aozasa
%A Eiichi Morii
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 3
%P 168-175
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100077

TY - JOUR
T1 - Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma
A1 - Ying Qiu
A1 - Zhu-ling Wang
A1 - Shu-qing Jin
A1 - Yu-fei Pu
A1 - Satoru Toyosawa
A1 - Katsuyuki Aozasa
A1 - Eiichi Morii
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 3
SP - 168
EP - 175
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100077


Abstract: 
Objective: In this study, we investigated the interrelationship between clinicopathologic findings and pre-B-cell leukemia transcription factor 2 (PBX2) expression in gingival squamous cell carcinoma (GSCC). Methods: Expression level of PBX2 was immunohistochemically examined in 66 GSCC subjects (30 men and 36 women) with ages ranging from 42 to 85 (median 64.5) years, in which staining intensity in tumor cells was categorized as either weaker (level 1) or equal to/stronger (level 2) than that in the endothelial cells. Results: PBX2 expression is correlated with valosin-containing protein (VCP) expression. Univariate and multivariate analyses revealed a high level of PBX2 expression to be a poor prognosticator for disease-free survival (DFS) and overall survival (OS), and PBX2 expression was an independent prognostic factor for both DFS and OS in GSCC. Conclusions: PBX2 expression level in GSCC is prognostic. PBX2 may be a useful marker to identify the potential for progression in GSCC.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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