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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.3 P.256-262


Primary age-related tauopathy in a Chinese cohort

Author(s):  Xin Wang, Lei Zhang, Hui Lu, Juan-Li Wu, Hua-Zheng Liang, Chong Liu, Qing-Qing Tao, Zhi-Ying Wu, Ke-Qing Zhu

Affiliation(s):  China Brain Bank and Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, and Department of Neurobiology, School of Medicine, Zhejiang University, Hangzhou 310058, China; more

Corresponding email(s):   zhukeqing@zju.edu.cn

Key Words:  Primaryage-relatedtauopathy, Neurofibrillary tangle, Transactive response DNA-binding protein 43 (TDP43), p62, Alzheimer’, s disease

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Xin Wang, Lei Zhang, Hui Lu, Juan-Li Wu, Hua-Zheng Liang, Chong Liu, Qing-Qing Tao, Zhi-Ying Wu, Ke-Qing Zhu. Primary age-related tauopathy in a Chinese cohort[J]. Journal of Zhejiang University Science B, 2020, 21(3): 256-262.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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DOI - 10.1631/jzus.B1900262

Primary age-related tauopathy (PART) is characterized by the presence of tau neurofibrillary tangles (NFTs) which are typically observed in alzheimer’;s disease (AD) brains, with few or without β-amyloid (Aβ) plaques. The diagnosis of PART can be categorized into “definite” or “possible” depending on the amount of Aβ plaques. Definite PART is diagnosed when NFTs are observed and the Braak stage is ≤IV, with Thal Aβ Phase 0 (Crary et al., 2014). According to the neuropathological diagnostic criteria, we reported that PART was frequently observed in the Chinese population according to our findings from specimens in our brain bank, with 47% of brain bank subjects meeting the criteria for PART. There is no consensus on the nature of PART. It remains to be elucidated whether PART is an early form of AD or a novel tauopathy (Duyckaerts et al., 2015; Jellinger et al., 2015).




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[22]List of electronic supplementary materials

[23]Table S1 Assessment of the altered protein expression

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