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Received: 2019-05-22

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.3 P.256-262

http://doi.org/10.1631/jzus.B1900262


Primary age-related tauopathy in a Chinese cohort


Author(s):  Xin Wang, Lei Zhang, Hui Lu, Juan-Li Wu, Hua-Zheng Liang, Chong Liu, Qing-Qing Tao, Zhi-Ying Wu, Ke-Qing Zhu

Affiliation(s):  China Brain Bank and Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, and Department of Neurobiology, School of Medicine, Zhejiang University, Hangzhou 310058, China; more

Corresponding email(s):   zhukeqing@zju.edu.cn

Key Words:  Primaryage-relatedtauopathy, Neurofibrillary tangle, Transactive response DNA-binding protein 43 (TDP43), p62, Alzheimer’, s disease


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Xin Wang, Lei Zhang, Hui Lu, Juan-Li Wu, Hua-Zheng Liang, Chong Liu, Qing-Qing Tao, Zhi-Ying Wu, Ke-Qing Zhu. Primary age-related tauopathy in a Chinese cohort[J]. Journal of Zhejiang University Science B, 2020, 21(3): 256-262.

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journal="Journal of Zhejiang University Science B",
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publisher="Zhejiang University Press & Springer",
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Abstract: 
Primary age-related tauopathy (PART) is characterized by the presence of tau neurofibrillary tangles (NFTs) which are typically observed in alzheimer’;s disease (AD) brains, with few or without β-amyloid (Aβ) plaques. The diagnosis of PART can be categorized into “definite” or “possible” depending on the amount of Aβ plaques. Definite PART is diagnosed when NFTs are observed and the Braak stage is ≤IV, with Thal Aβ Phase 0 (Crary et al., 2014). According to the neuropathological diagnostic criteria, we reported that PART was frequently observed in the Chinese population according to our findings from specimens in our brain bank, with 47% of brain bank subjects meeting the criteria for PART. There is no consensus on the nature of PART. It remains to be elucidated whether PART is an early form of AD or a novel tauopathy (Duyckaerts et al., 2015; Jellinger et al., 2015).

原发性衰老相关性tau病在中国人群中的临床病理学研究

目的:分析中国人群中原发性衰老相关性tau病(PART)的临床病理学特点,并比较其与老年性痴呆之间的差异.
创新点:PART为新近提出的概念,其与老年性痴呆的关系尚存在争论.目前未见针对中国人群PART的相关报道.本文首次报道了浙江大学医学院中国人脑库中的PART的临床病理学特点.
方法:回顾性分析相关病例,严格纳入标准.PART在中国人群中常见,50岁以上人群占47%.平均年龄(76±12)岁,女性14例(30%),男性32例(70%).免疫组织化学法显示,按磷酸化tau的Braak分期,PART大多为I到Ш期.异常蛋白TDP43和p62在PART中高表达,分别为67%和70%;在老年性痴呆中分别为83%和83%.TDP43和p62共表达在PART为55%,在老年性痴呆为79%.其中海马为PART常见累及部位,TDP43为61%,p62为63%.仅4%的PART患者表现为轻度认知障碍.
结论:PART在中国人群中常见;PART大多无明显痴呆症状;异常蛋白TDP43和p62在PART中高表达,与老年性痴呆相比存在差异.

关键词:原发性衰老相关性tau病(PART);老年性痴呆;Tau蛋白;TDP43;p62

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[22]List of electronic supplementary materials

[23]Table S1 Assessment of the altered protein expression

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