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CLC number: Q752

On-line Access: 2019-10-09

Received: 2019-06-24

Revision Accepted: 2019-07-30

Crosschecked: 2019-09-12

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.11 P.920-927

http://doi.org/10.1631/jzus.B1900336


Alternative role of noncoding RNAs: coding and noncoding properties


Author(s):  Gui-Zhen Zheng, Wei Li, Zhi-Yong Liu

Affiliation(s):  Department of Emergency Internal Medicine, Shanghai East Hospital, Tongji University, Shanghai 200120, China; more

Corresponding email(s):   liuzy271@163.com

Key Words:  Non-coding RNA, Biological function, Micropeptides, Cellular stress


Gui-Zhen Zheng, Wei Li, Zhi-Yong Liu. Alternative role of noncoding RNAs: coding and noncoding properties[J]. Journal of Zhejiang University Science B, 2019, 20(11): 920-927.

@article{title="Alternative role of noncoding RNAs: coding and noncoding properties",
author="Gui-Zhen Zheng, Wei Li, Zhi-Yong Liu",
journal="Journal of Zhejiang University Science B",
volume="20",
number="11",
pages="920-927",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900336"
}

%0 Journal Article
%T Alternative role of noncoding RNAs: coding and noncoding properties
%A Gui-Zhen Zheng
%A Wei Li
%A Zhi-Yong Liu
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 11
%P 920-927
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900336

TY - JOUR
T1 - Alternative role of noncoding RNAs: coding and noncoding properties
A1 - Gui-Zhen Zheng
A1 - Wei Li
A1 - Zhi-Yong Liu
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 11
SP - 920
EP - 927
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900336


Abstract: 
Noncoding RNAs (ncRNAs) have played a critical role in cellular biological functions. Recently, some peptides or proteins originating from annotated ncRNAs were identified in organism development and various diseases. Here, we briefly review several novel peptides translated by annotated ncRNAs and related key functions. In addition, we summarize the potential mechanism of bifunctional ncRNAs and propose a specific “switch” triggering the transformation from the noncoding to the coding state under certain stimuli or cellular stress. The coding properties of ncRNAs and their peptide products may provide a novel horizon in proteomic research and can be regarded as a potential therapeutic target for the treatment of various diseases.

非编码RNA的选择性作用:编码与非编码特性研究进展

概要:非编码RNA在细胞生物学功能中发挥着重要作用.近年来,研究人员在生物发育和多种疾病中发现了一些由非编码RNA(ncRNA)编码产生的多肽或蛋白质.在本文中,我们简要总结了几种由ncRNA翻译的微肽分子及其功能.此外,我们还总结了调控ncRNA的可能机制,并且提出了一个生物"开关",即细胞在一定的刺激或应激状态下,能够触发ncRNA分子由非编码状态到编码状态的转换.ncRNA的潜在编码特性及其微肽产物为蛋白质组学研究提供了一个新的视角,有希望为多种疾病提供新的治疗靶点.
关键词:非编码RNA;生物功能;微肽;细胞应激

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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