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Received: 2023-10-17

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Bo-lun Zhou

https://orcid.org/0000-0001-8143-4852

Cai-ping Ren

https://orcid.org/0000-0001-6880-7394

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.2 P.122-136

http://doi.org/10.1631/jzus.B1900422


Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis


Author(s):  Wei Zhu, Bo-lun Zhou, Li-juan Rong, Li Ye, Hong-juan Xu, Yao Zhou, Xue-jun Yan, Wei-dong Liu, Bin Zhu, Lei Wang, Xing-jun Jiang, Cai-ping Ren

Affiliation(s):  NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China

Corresponding email(s):   rencaiping@csu.edu.cn

Key Words:  Polypyrimidine tract-binding protein 1 (PTBP1), Alternative splicing, Glycolysis, M2 isoform of pyruvate kinase (PKM2), Cancer


Wei Zhu, Bo-lun Zhou, Li-juan Rong, Li Ye, Hong-juan Xu, Yao Zhou, Xue-jun Yan, Wei-dong Liu, Bin Zhu, Lei Wang, Xing-jun Jiang, Cai-ping Ren. Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis[J]. Journal of Zhejiang University Science B, 2020, 21(2): 122-136.

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author="Wei Zhu, Bo-lun Zhou, Li-juan Rong, Li Ye, Hong-juan Xu, Yao Zhou, Xue-jun Yan, Wei-dong Liu, Bin Zhu, Lei Wang, Xing-jun Jiang, Cai-ping Ren",
journal="Journal of Zhejiang University Science B",
volume="21",
number="2",
pages="122-136",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900422"
}

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%A Wei Zhu
%A Bo-lun Zhou
%A Li-juan Rong
%A Li Ye
%A Hong-juan Xu
%A Yao Zhou
%A Xue-jun Yan
%A Wei-dong Liu
%A Bin Zhu
%A Lei Wang
%A Xing-jun Jiang
%A Cai-ping Ren
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%P 122-136
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900422

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T1 - Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis
A1 - Wei Zhu
A1 - Bo-lun Zhou
A1 - Li-juan Rong
A1 - Li Ye
A1 - Hong-juan Xu
A1 - Yao Zhou
A1 - Xue-jun Yan
A1 - Wei-dong Liu
A1 - Bin Zhu
A1 - Lei Wang
A1 - Xing-jun Jiang
A1 - Cai-ping Ren
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 2
SP - 122
EP - 136
%@ 1673-1581
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PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900422


Abstract: 
polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is expressed in almost all cell types in humans, unlike the other proteins of the PTBP family. PTBP1 mediates several cellular processes in certain types of cells, including the growth and differentiation of neuronal cells and activation of immune cells. Its function is regulated by various molecules, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and RNA-binding proteins. PTBP1 plays roles in various diseases, particularly in some cancers, including colorectal cancer, renal cell cancer, breast cancer, and glioma. In cancers, it acts mainly as a regulator of glycolysis, apoptosis, proliferation, tumorigenesis, invasion, and migration. The role of PTBP1 in cancer has become a popular research topic in recent years, and this research has contributed greatly to the formulation of a useful therapeutic strategy for cancer. In this review, we summarize recent findings related to PTBP1 and discuss how it regulates the development of cancer cells.

多聚嘧啶区结合蛋白1(PTBP1)在选择性剪接、糖酵解和肿瘤发生中的作用

概要:多聚嘧啶区结合蛋白1(PTBP1)在多种疾病,尤其是在某些癌症中发挥作用.为明确PTBP1在人体的生物学功能,本文汇总了调控PTBP1相关的miRNA、长链非编码RNA(lncRNA)和RNA结合蛋白.另外,我们重点阐述了PTBP1充当糖酵解、细胞凋亡、增殖、肿瘤发生、侵袭和迁移的调节剂,并为制定有用的癌症治疗策略做出了潜在贡献.
关键词:多聚嘧啶区结合蛋白1(PTBP1);选择性剪接;糖酵解;丙酮酸激酶M2亚型(PKM2);癌症

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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