Full Text:   <1431>

Summary:  <1288>

CLC number: Q39

On-line Access: 2019-05-15

Received: 2019-01-24

Revision Accepted: 2019-04-16

Crosschecked: 2019-05-03

Cited: 0

Clicked: 2929

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Ai-fu Lin

https://orcid.org/0000-0002-3968-3617

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.6 P.488-495

http://doi.org/10.1631/jzus.B1900039


Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment


Author(s):  Jie Luo, Yan Xiong, Pei-Fen Fu, En-Chun Li, Lei Qu, Xiao Fan, Zhi-Jian Cai, Ai-Fu Lin

Affiliation(s):  Department of Gynecology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; more

Corresponding email(s):   linaifu@zju.edu.cn, caizj@zju.edu.cn

Key Words:  Exosome, Long non-coding RNA (lncRNA), Biosynthesis, Biomarker, Drug resistance


Jie Luo, Yan Xiong, Pei-Fen Fu, En-Chun Li, Lei Qu, Xiao Fan, Zhi-Jian Cai, Ai-Fu Lin. Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment[J]. Journal of Zhejiang University Science B, 2019, 20(6): 488-495.

@article{title="Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment",
author="Jie Luo, Yan Xiong, Pei-Fen Fu, En-Chun Li, Lei Qu, Xiao Fan, Zhi-Jian Cai, Ai-Fu Lin",
journal="Journal of Zhejiang University Science B",
volume="20",
number="6",
pages="488-495",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900039"
}

%0 Journal Article
%T Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment
%A Jie Luo
%A Yan Xiong
%A Pei-Fen Fu
%A En-Chun Li
%A Lei Qu
%A Xiao Fan
%A Zhi-Jian Cai
%A Ai-Fu Lin
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 6
%P 488-495
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900039

TY - JOUR
T1 - Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment
A1 - Jie Luo
A1 - Yan Xiong
A1 - Pei-Fen Fu
A1 - En-Chun Li
A1 - Lei Qu
A1 - Xiao Fan
A1 - Zhi-Jian Cai
A1 - Ai-Fu Lin
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 6
SP - 488
EP - 495
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900039


Abstract: 
exosomes and long non-coding RNAs (lncRNAs) are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression. The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance. In this review, we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research. These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.

外泌体lncRNA研究进展及其肿瘤靶向潜质

概要:外泌体和长链非编码RNA(lncRNA)与肿瘤等危害人类健康重大疾病的发生发展密切相关.对外泌体中lncRNA研究的深入解析有助于人们更加全面地了解癌症发生发展机理机制,并有助于为进一步肿瘤精准靶向治疗提供新的潜在标志物及临床靶点.本综述阐述了外泌体的发生过程及其内容lncRNA,并进一步通过深入总结外泌体lncRNA在肿瘤临床药物耐受中的作用,评估其肿瘤靶向潜质,揭示其作为潜在有效靶向治疗靶点和诊疗标志物的前景意义.
关键词:外泌体;长链非编码RNA(lncRNA);生物合成;生物标志物;肿瘤靶点;临床耐药

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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