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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.4 P.280-290


Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects

Author(s):  Cong-Ying Song, Ying-Ge Xu, Yuan-Qiang Lu

Affiliation(s):  Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   luyuanqiang@zju.edu.cn

Key Words:  Tripterygium wilfordii Hook F, Anti-inflammation, Immunosuppression

Cong-Ying Song, Ying-Ge Xu, Yuan-Qiang Lu. Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects[J]. Journal of Zhejiang University Science B, 2020, 21(4): 280-290.

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%T Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects
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T1 - Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects
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A1 - Ying-Ge Xu
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DOI - 10.1631/jzus.B1900607

Tripterygium wilfordii Hook F has significant anti-inflammatory and immunosuppressive properties and is widely used for treating autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and kidney disease, especially in traditional Chinese medicine. The mechanisms underlying its effects may be diverse but they remain unclear, and its toxicity and side effects limit its wider clinical application. This review summarizes the clinical application of Tripterygium wilfordii Hook F in recent years, as well as the results of studies into its mechanisms and toxicity, to provide a reference for its future clinical application.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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