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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.4 P.280-290

http://doi.org/10.1631/jzus.B1900607


Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects


Author(s):  Cong-Ying Song, Ying-Ge Xu, Yuan-Qiang Lu

Affiliation(s):  Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   luyuanqiang@zju.edu.cn

Key Words:  Tripterygium wilfordii Hook F, Anti-inflammation, Immunosuppression


Cong-Ying Song, Ying-Ge Xu, Yuan-Qiang Lu. Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects[J]. Journal of Zhejiang University Science B, 2020, 21(4): 280-290.

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%T Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects
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%A Yuan-Qiang Lu
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900607

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T1 - Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects
A1 - Cong-Ying Song
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A1 - Yuan-Qiang Lu
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EP - 290
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900607


Abstract: 
Tripterygium wilfordii Hook F has significant anti-inflammatory and immunosuppressive properties and is widely used for treating autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and kidney disease, especially in traditional Chinese medicine. The mechanisms underlying its effects may be diverse but they remain unclear, and its toxicity and side effects limit its wider clinical application. This review summarizes the clinical application of Tripterygium wilfordii Hook F in recent years, as well as the results of studies into its mechanisms and toxicity, to provide a reference for its future clinical application.

雷公藤在免疫介导的炎症疾病中的应用:研究进展及展望

概要:雷公藤作为中国传统药材的瑰宝,具有较强的抗炎及免疫抑制作用,临床上广泛应用于类风湿性关节炎、系统性红斑狼疮、肾脏疾病等自身免疫性及炎症性疾病.由于雷公藤对于自身免疫疾病疗效显著,且没有激素的副作用,近年来备受国内外研究者关注,大量研究开始探究其抗炎及免疫抑制的潜在机制.而雷公藤本身也存在毒副作用,限制了其在临床更广泛的应用.本文总结了近年来雷公藤在免疫相关炎性疾病临床应用情况,雷公藤抗炎和免疫调节的机制以及目前雷公藤减毒的方法,旨在更好地帮助临床医生及科研工作者理解雷公藤的生物特性及作用机制,为临床应用及推广提供参考依据.
关键词:雷公藤;抗炎;免疫抑制

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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