CLC number: R541.9
On-line Access: 2020-07-07
Received: 2019-12-05
Revision Accepted: 2020-02-28
Crosschecked: 2020-06-05
Cited: 0
Clicked: 3406
Kun Zhao, Chuan-xi Yang, Peng Li, Wei Sun, Xiang-qing Kong. Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system[J]. Journal of Zhejiang University Science B, 2020, 21(7): 509-523.
@article{title="Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system",
author="Kun Zhao, Chuan-xi Yang, Peng Li, Wei Sun, Xiang-qing Kong",
journal="Journal of Zhejiang University Science B",
volume="21",
number="7",
pages="509-523",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900680"
}
%0 Journal Article
%T Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system
%A Kun Zhao
%A Chuan-xi Yang
%A Peng Li
%A Wei Sun
%A Xiang-qing Kong
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 7
%P 509-523
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900680
TY - JOUR
T1 - Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system
A1 - Kun Zhao
A1 - Chuan-xi Yang
A1 - Peng Li
A1 - Wei Sun
A1 - Xiang-qing Kong
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 7
SP - 509
EP - 523
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900680
Abstract: As the most prevalent and abundant transcriptional modification in the eukaryotic genome, the continuous and dynamic regulation of N6-methyladenosine (m6A) has been shown to play a vital role in physiological and pathological processes of cardiovascular diseases (CVDs), such as ischemic heart failure (HF), myocardial hypertrophy, myocardial infarction (MI), and cardiomyogenesis. Regulation is achieved by modulating the expression of m6A enzymes and their downstream cardiac genes. In addition, this process has a major impact on different aspects of internal biological metabolism and several other external environmental effects associated with the development of CVDs. However, the exact molecular mechanism of m6A epigenetic regulation has not been fully elucidated. In this review, we outline recent advances and discuss potential therapeutic strategies for managing m6A in relation to several common CVD-related metabolic disorders and external environmental factors. Note that an appropriate understanding of the biological function of m6A in the cardiovascular system will pave the way towards exploring the mechanisms responsible for the development of other CVDs and their associated symptoms. Finally, it can provide new insights for the development of novel therapeutic agents for use in clinical practice.
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