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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.11 P.856-870


Application of antigenic biomarkers for Mycobacterium tuberculosis

Author(s):  Elba Rodrguez-Hernndez, Laura Itzel Quintas-Granados, Susana Flores-Villalva, Jorge Germinal Cant-Alarcn, Feliciano Milin-Suazo

Affiliation(s):  Instituto Nacional de Investigaciones Forestales, Agrcolas y Pecuarias (INIFAP), Centro Nacional de Investigacin Disciplinaria en Fisiologa y Mejoramiento Animal, Km. 1 Carretera a Coln, Ajuchitln Coln, 76280, Coln, Quertaro, Mxico; more

Corresponding email(s):   rodriguez.elba@inifap.gob.mx

Key Words:  Mycobacterium tuberculosis, Recombinant antigen, Diagnostics, Biomarker

Elba Rodrguez-Hernndez, Laura Itzel Quintas-Granados, Susana Flores-Villalva, Jorge Germinal Cant-Alarcn, Feliciano Milin-Suazo. Application of antigenic biomarkers for Mycobacterium tuberculosis[J]. Journal of Zhejiang University Science B, 2020, 21(11): 856-870.

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author="Elba Rodrguez-Hernndez, Laura Itzel Quintas-Granados, Susana Flores-Villalva, Jorge Germinal Cant-Alarcn, Feliciano Milin-Suazo",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Application of antigenic biomarkers for Mycobacterium tuberculosis
%A Elba Rodrguez-Hernndez
%A Laura Itzel Quintas-Granados
%A Susana Flores-Villalva
%A Jorge Germinal Cant-Alarcn
%A Feliciano Milin-Suazo
%J Journal of Zhejiang University SCIENCE B
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%N 11
%P 856-870
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%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000325

T1 - Application of antigenic biomarkers for Mycobacterium tuberculosis
A1 - Elba Rodrguez-Hernndez
A1 - Laura Itzel Quintas-Granados
A1 - Susana Flores-Villalva
A1 - Jorge Germinal Cant-Alarcn
A1 - Feliciano Milin-Suazo
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 11
SP - 856
EP - 870
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000325

The study and characterization of biomolecules involved in the interaction between mycobacteria and their hosts are crucial to determine their roles in the invasion process and provide basic knowledge about the biology and pathogenesis of disease. Promising new biomarkers for diagnosis and immunotherapy have emerged recently. Mycobacterium is an ancient pathogen that has developed complex strategies for its persistence in the host and environment, likely based on the complexity of the network of interactions between the molecules involved in infection. Several biomarkers have received recent attention in the process of developing rapid and reliable detection techniques for tuberculosis. Among the most widely investigated antigens are CFP-10 (10-kDa culture filtrate protein), ESAT-6 (6-kDa early secretory antigenic target), Ag85A, Ag85B, CFP-7, and PPE18. Some of these antigens have been proposed as biomarkers to assess the key elements of the response to infection of both the pathogen and host. The design of novel and accurate diagnostic methods is essential for the control of tuberculosis worldwide. Presently, the diagnostic methods are based on the identification of molecules in the humoral response in infected individuals. Therefore, these tests depend on the capacity of the host to develop an immune response, which usually is heterogeneous. In the last 20 years, special attention has been given to the design of multiantigenic diagnostic methods to improve the levels of sensitivity and specificity. In this review, we summarize the state of the art in the study and use of mycobacterium biomolecules with the potential to support novel tuberculosis control strategies.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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