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On-line Access: 2021-04-08

Received: 2020-09-02

Revision Accepted: 2021-01-03

Crosschecked: 2021-03-16

Cited: 0

Clicked: 2003

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jing ZHOU

https://orcid.org/0000-0001-6190-8053

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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.4 P.310-317

http://doi.org/10.1631/jzus.B2000523


Structural and physiological changes of the human body upon SARS-CoV-2 infection


Author(s):  Zhonglin WU, Qi ZHANG, Guo YE, Hui ZHANG, Boon Chin HENG, Yang FEI, Bing ZHAO, Jing ZHOU

Affiliation(s):  Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; more

Corresponding email(s):   zhoujing@zju.edu.cn

Key Words:  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), Pathological change, Pathogenesis


Zhonglin WU, Qi ZHANG, Guo YE, Hui ZHANG, Boon Chin HENG, Yang FEI, Bing ZHAO, Jing ZHOU. Structural and physiological changes of the human body upon SARS-CoV-2 infection[J]. Journal of Zhejiang University Science B, 2021, 22(4): 310-317.

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journal="Journal of Zhejiang University Science B",
volume="22",
number="4",
pages="310-317",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000523"
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%T Structural and physiological changes of the human body upon SARS-CoV-2 infection
%A Zhonglin WU
%A Qi ZHANG
%A Guo YE
%A Hui ZHANG
%A Boon Chin HENG
%A Yang FEI
%A Bing ZHAO
%A Jing ZHOU
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%I Zhejiang University Press & Springer
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T1 - Structural and physiological changes of the human body upon SARS-CoV-2 infection
A1 - Zhonglin WU
A1 - Qi ZHANG
A1 - Guo YE
A1 - Hui ZHANG
A1 - Boon Chin HENG
A1 - Yang FEI
A1 - Bing ZHAO
A1 - Jing ZHOU
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SP - 310
EP - 317
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2000523


Abstract: 
Since December 2019, the novel coronavirus (severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) has spread to many countries around the world, developing into a global pandemic with increasing numbers of deaths reported worldwide. To data, although some vaccines have been developed, there are no ideal drugs to treat novel coronavirus pneumonia (coronavirus disease 2019 (COVID-19)). By examining the structure of the coronavirus and briefly describing its possible pathogenesis based on recent autopsy reports conducted by various teams worldwide, this review analyzes the possible structural and functional changes of the human body upon infection with SARS-CoV-2. We observed that the most prominent pathological changes in COVID-19 patients are diffuse alveolar damage (DAD) of the lungs and microthrombus formation, resulting in an imbalance of the ventilation/perfusion ratio and respiratory failure. Although direct evidence of viral infection can also be found in other organs and tissues, the viral load is relatively small. The conclusion that the injuries of the extra-pulmonary organs are directly caused by the virus needs further investigation.

SARS-CoV-2感染对人体结构和生理的影响

概要:自2019年12月以来,新型冠状病毒(SARS-CoV-2)已蔓延至世界许多国家,目前已发展成为全球大流行,且全世界报告的死亡人数在不断增加。迄今为止,虽然已有一些疫苗研发出来,但仍没有理想的药物来治疗新型冠状病毒性肺炎(COVID-19)。本文通过对冠状病毒结构的研究,并根据世界各国最近的尸检报告简要描述其可能的发病机制,进一步分析了感染SARS-CoV-2后人体可能发生的结构和功能变化。我们观察到COVID-19患者最显著的病理改变是肺部弥漫性肺泡损伤(DAD)和微血栓形成,导致通气/灌注比失衡和呼吸衰竭。虽然在其他器官和组织中也可以发现病毒感染的直接证据,但病毒载量相对较小。肺外器官的损伤是否是由病毒直接引起的,有待进一步研究。

关键词:新型冠状病毒(SARS-CoV-2);新型冠状病毒性肺炎(COVID-19);病理改变;发病机制

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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