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On-line Access: 2024-08-27
Received: 2023-10-17
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Citations: Bibtex RefMan EndNote GB/T7714
Zhifeng ZHOU, Huang KUANG, Yuexian MA, Ling ZHANG. Application of extracorporeal therapies in critically ill COVID-19 patients[J]. Journal of Zhejiang University Science B, 2021, 22(9): 701-717.
@article{title="Application of extracorporeal therapies in critically ill COVID-19 patients",
author="Zhifeng ZHOU, Huang KUANG, Yuexian MA, Ling ZHANG",
journal="Journal of Zhejiang University Science B",
volume="22",
number="9",
pages="701-717",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100344"
}
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%A Ling ZHANG
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%DOI 10.1631/jzus.B2100344
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T1 - Application of extracorporeal therapies in critically ill COVID-19 patients
A1 - Zhifeng ZHOU
A1 - Huang KUANG
A1 - Yuexian MA
A1 - Ling ZHANG
J0 - Journal of Zhejiang University Science B
VL - 22
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SP - 701
EP - 717
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100344
Abstract: The coronavirus disease 2019 (COVID-19) pandemic is a major public health event caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has spread widely all over the world. A high proportion of patients become severely or critically ill, and suffer high mortality due to respiratory failure and multiple organ dysfunction. Therefore, providing timely and effective treatment for critically ill patients is essential to reduce overall mortality. Convalescent plasma therapy and pharmacological treatments, such as aerosol inhalation of interferon-α (IFN-α), corticosteroids, and tocilizumab, have all been applied in clinical practice; however, their effects remain controversial. Recent studies have shown that extracorporeal therapies might have a potential role in treating critically ill COVID-19 patients. In this review, we examine the application of continuous renal replacement therapy (CRRT), therapeutic plasma exchange (TPE), hemoadsorption (HA), extracorporeal membrane oxygenation (ECMO), and extracorporeal carbon dioxide removal (ECCO2R) in critically ill COVID-19 patients to provide support for the further diagnosis and treatment of COVID-19.
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