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On-line Access: 2021-09-10
Received: 2021-04-12
Revision Accepted: 2021-06-20
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Citations: Bibtex RefMan EndNote GB/T7714
Zhifeng ZHOU, Huang KUANG, Yuexian MA, Ling ZHANG. Application of extracorporeal therapies in critically ill COVID-19 patients[J]. Journal of Zhejiang University Science B, 2021, 22(9): 701-717.
@article{title="Application of extracorporeal therapies in critically ill COVID-19 patients",
author="Zhifeng ZHOU, Huang KUANG, Yuexian MA, Ling ZHANG",
journal="Journal of Zhejiang University Science B",
volume="22",
number="9",
pages="701-717",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100344"
}
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%DOI 10.1631/jzus.B2100344
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T1 - Application of extracorporeal therapies in critically ill COVID-19 patients
A1 - Zhifeng ZHOU
A1 - Huang KUANG
A1 - Yuexian MA
A1 - Ling ZHANG
J0 - Journal of Zhejiang University Science B
VL - 22
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SP - 701
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%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100344
Abstract: The coronavirus disease 2019 (COVID-19) pandemic is a major public health event caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has spread widely all over the world. A high proportion of patients become severely or critically ill, and suffer high mortality due to respiratory failure and multiple organ dysfunction. Therefore, providing timely and effective treatment for critically ill patients is essential to reduce overall mortality. Convalescent plasma therapy and pharmacological treatments, such as aerosol inhalation of interferon-α (IFN-α), corticosteroids, and tocilizumab, have all been applied in clinical practice; however, their effects remain controversial. Recent studies have shown that extracorporeal therapies might have a potential role in treating critically ill COVID-19 patients. In this review, we examine the application of continuous renal replacement therapy (CRRT), therapeutic plasma exchange (TPE), hemoadsorption (HA), extracorporeal membrane oxygenation (ECMO), and extracorporeal carbon dioxide removal (ECCO2R) in critically ill COVID-19 patients to provide support for the further diagnosis and treatment of COVID-19.
[1]AdapaS, AeddulaNR, KonalaVM, et al., 2020. COVID-19 and renal failure: challenges in the delivery of renal replacement therapy. J Clin Med Res, 12(5):276-285.
[2]AdeliSH, AsghariA, TabarraiiR, et al., 2020. Therapeutic plasma exchange as a rescue therapy in patients with coronavirus disease 2019: a case series. Pol Arch Intern Med, 130(5):455-458.
[3]AkkantiB, JagpalS, DarwishR, et al., 2021. Physiologic improvement in respiratory acidosis using extracorporeal CO2 removal with hemolung respiratory assist system in the management of severe respiratory failure from coronavirus disease 2019. Crit Care Explor, 3(3):e0372.
[4]Al-FaresA, PettenuzzoT, del SorboL, 2019. Extracorporeal life support and systemic inflammation. Intens Care Med Exp, 7(S1):46.
[5]AlharthyA, FaqihiF, MemishZA, et al., 2021. Continuous renal replacement therapy with the addition of cytosorb cartridge in critically ill patients with COVID-19 plus acute kidney injury: a case-series. Artif Organs, 45(5):E101-E112.
[6]AsgharpourM, MehdinezhadH, BayaniM, et al., 2020. Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19). BMC Nephrol, 21:356.
[7]AtanR, PeckLC, ProwleJ, et al., 2018. A double-blind randomized controlled trial of high cutoff versus standard hemofiltration in critically ill patients with acute kidney injury. Crit Care Med, 46(10):e988-e994.
[8]AttallahN, GuptaS, MadhyasthaR, et al., 2021. Anticoagulation in COVID-19 patients requiring continuous renal replacement therapy. Anaesth Crit Care Pain Med, 40(3):100841.
[9]AzoulayE, ZafraniL, MirouseA, et al., 2020. Clinical phenotypes of critically ill COVID-19 patients. Intensive Care Med, 46:1651-1652.
[10]BerhésM, FábiánÁ, LászlóI, et al., 2020. Organ replacement therapy and life-supporting treatment modalities in critically ill COVID-19 patients. Orv Hetil, 161(17):704-709.
[11]BhatrajuPK, GhassemiehBJ, NicholsM, et al., 2020. COVID-19 in critically ill patients in the seattle region—case series. N Engl J Med, 382(21):2012-2022.
[12]BurkeE, HaberE, PikeCW, et al., 2021. Outcomes of renal replacement therapy in the critically ill with COVID-19. Med Intensiva, 45(6):325-331.
[13]CamboniD, PhilipA, SchmidC, et al., 2019. Double, triple and quadruple cannulation for veno-arterial extracorporeal membrane oxygenation support: is there a limit? Ann Cardiothorac Surg, 8(1):151-159.
[14]CaponeS, AbramyanS, RossB, et al., 2020. Characterization of critically ill COVID-19 patients at a Brooklyn safety-net hospital. Cureus, 12(8):e9809.
[15]ChaRH, JohJS, JeongI, et al., 2015. Renal complications and their prognosis in Korean patients with middle east respiratory syndrome-coronavirus from the central MERS-CoV designated hospital. J Korean Med Sci, 30(12):1807-1814.
[16]ChenY, WangSH, HuangJR, et al., 2021. Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19. Clin Hemorheol Microcirc, 78(2):199-207.
[17]ChengYC, LuoR, WangK, et al., 2020. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int, 97(5):829-838.
[18]Chinese Society of Nephrology, Professional Committee of Nephrology, 2020. Expert consensus on special blood purification technics in patients with corona virus disease 2019. Chin J Intern Med, 59(11):847-853 (in Chinese).
[19]ChuaHR, MacLarenG, ChoongLHL, et al., 2020. Ensuring sustainability of continuous kidney replacement therapy in the face of extraordinary demand: lessons from the COVID-19 pandemic. Am J Kidney Dis, 76(3):392-400.
[20]ColaneriM, ValsecchiP, PerottiL, et al., 2020. Running out of bullets: the challenging management of acute hepatitis and SARS-COV-2 from the SMatteo COvid19 Registry (SMACORE). Liver Int, 40(11):2655-2659.
[21]CombesA, SchmidtM, HodgsonCL, et al., 2020. Extracorporeal life support for adults with acute respiratory distress syndrome. Intensive Care Med, 46:2464-2476.
[22]DaoudAM, SolimanKM, AliHK, 2021. Potential limitations of plasmapheresis in treatment of COVID-19 patients: how to overcome them? Ther Apher Dial, 25(3):350.
[23]DastanF, SaffaeiA, MortazaviSM, et al., 2020. Continues renal replacement therapy (CRRT) with disposable hemoperfusion cartridge: a promising option for severe COVID-19. J Glob Antimicrob Resist, 21:340-341.
[24]DeepA, BansalM, RicciZ, 2021. Acute kidney injury and special considerations during renal replacement therapy in children with coronavirus disease-19: perspective from the critical care nephrology section of the European Society of Paediatric and Neonatal Intensive Care. Blood Purif, 50(2):150-160.
[25]DiamantiAP, RosadoMM, PioliC, et al., 2020. Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern: the fragile balance between infections and autoimmunity. Int J Mol Sci, 21(9):3330.
[26]DinMAU, BoppanaLKT, 2020. An update on the 2019-nCoV outbreak. Am J Infect Control, 48(6):713.
[27]DoherMP, de CarvalhoFRT, SchererPF, et al., 2021. Acute kidney injury and renal replacement therapy in critically ill COVID-19 patients: risk factors and outcomes: a single-center experience in Brazil. Blood Purif, 50(4-5):520-530.
[28]DongMZ, ZhangJ, MaXF, et al., 2020. ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19. Biomed Pharmacother, 131:110678.
[29]FaqihiF, AlharthyA, AlodatM, et al., 2020. Therapeutic plasma exchange in adult critically ill patients with life-threatening SARS-CoV-2 disease: a pilot study. J Crit Care, 60:328-333.
[30]FardetL, FèveB, 2014. Systemic glucocorticoid therapy: a review of its metabolic and cardiovascular adverse events. Drugs, 74(15):1731-1745.
[31]FayadAI, BuamschaDG, CiapponiA, 2016. Intensity of continuous renal replacement therapy for acute kidney injury. Cochrane Database Syst Rev, 10(10):CD010613.
[32]FernandezJ, Gratacos-GinèsJ, OlivasP, et al., 2020. Plasma exchange: an effective rescue therapy in critically ill patients with coronavirus disease 2019 infection. Crit Care Med, 48(12):e1350-e1355.
[33]FuD, YangB, XuJ, et al., 2020. COVID-19 infection in a patient with end-stage kidney disease. Nephron, 144(5):245-247.
[34]GarcíaLF, 2020. Immune response, inflammation, and the clinical spectrum of COVID-19. Front Immunol, 11:1441.
[35]GrazioliA, AthaleJ, TanakaK, et al., 2020. Perioperative applications of therapeutic plasma exchange in cardiac surgery: a narrative review. J Cardiothorac Vasc Anesth, 34(12):3429-3443.
[36]GuanWJ, NiZY, HuY, et al., 2020. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med, 382(18):1708-1720.
[37]GucyetmezB, AtalanHK, SertdemirI, et al., 2020. Therapeutic plasma exchange in patients with COVID-19 pneumonia in intensive care unit: a retrospective study. Crit Care, 24:492.
[38]HaaseM, BellomoR, BaldwinI, et al., 2007. Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: a phase 1 randomized trial. Am J Kidney Dis, 50(2):296-304.
[39]HazzardI, JonesS, QuinnT, 2015. Coupled plasma haemofiltration filtration in severe sepsis: systematic review and meta-analysis. J R Army Med Corps, 161(S1):i17-i22.
[40]HoffmannM, Kleine-WeberH, SchroederS, et al., 2020. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, 181(2):271-280.e8.
[41]HonorePM, MugishaA, KugenerL, et al., 2020. Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: we are not sure. Crit Care, 24:226.
[42]HuangCL, WangYM, LiXW, et al., 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395(10223):497-506.
[43]Husain-SyedF, BirkHW, WilhelmJ, et al., 2020. Extracorporeal carbon dioxide removal using a renal replacement therapy platform to enhance lung-protective ventilation in hypercapnic patients with coronavirus disease 2019-associated acute respiratory distress syndrome. Front Med, 7:598379.
[44]IzdaV, JeffriesMA, SawalhaAH, 2021. COVID-19: a review of therapeutic strategies and vaccine candidates. Clin Immunol, 222:108634.
[45]JaiswalV, NasaP, RaoufM, et al., 2021. Therapeutic plasma exchange followed by convalescent plasma transfusion in critical COVID-19-an exploratory study. Int J Infect Dis, 102:332-334.
[46]JinYH, CaiL, ChengZS, et al., 2020. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil Med Res, 7:4.
[47]Joannes-BoyauO, HonoréPM, PerezP, et al., 2013. High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial. Intensive Care Med, 39:1535-1546.
[48]JonckheerJ, SpapenH, DebainA, et al., 2019. CO2 and O2 removal during continuous veno-venous hemofiltration: a pilot study. BMC Nephrol, 20:222.
[49]KadeG, SpaleniakS, AntosiewiczS, 2020. Continuous renal replacement therapy as a treatment of selected acute intoxications. Pol Merkur Lekarski, 49(286):250-254.
[50]KamranSM, MirzaZEH, NaseemA, et al., 2021. Therapeutic plasma exchange for coronavirus disease-2019 triggered cytokine release syndrome; a retrospective propensity matched control study. PLoS ONE, 16(1):e0244853.
[51]KatagiriD, IshikaneM, OgawaT, et al., 2021a. Continuous renal replacement therapy for a patient with severe COVID-19. Blood Purif, 50(1):129-131.
[52]KatagiriD, IshikaneM, AsaiY, et al., 2021b. Direct hemoperfusion using a polymyxin B-immobilized polystyrene column for COVID-19. J Clin Apher, 36(3):313-321.
[53]KhamisF, Al-ZakwaniI, al HashmiS, et al., 2020. Therapeutic plasma exchange in adults with severe COVID-19 infection. Int J Infect Dis, 99:214-218.
[54]KoxM, WaaldersNJB, KooistraEJ, et al., 2020. Cytokine levels in critically ill patients with COVID-19 and other conditions. JAMA, 324(15):1565-1567.
[55]LiL, LiRR, WuZX, et al., 2020. Therapeutic strategies for critically ill patients with COVID-19. Ann Intensive Care, 10:45.
[56]LiQ, GuanXH, WuP, et al., 2020. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med, 382(13):1199-1207.
[57]LinJH, ChenYC, LuCL, et al., 2020. Application of plasma exchange in association with higher dose CVVH in Cytokine Storm Complicating COVID-19. J Formos Med Assoc, 119(6):1116-1118.
[58]LuRJ, ZhaoX, LiJ, et al., 2020. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet, 395(10224):565-574.
[59]LuoS, YangLJ, WangC, et al., 2020. Clinical observation of 6 severe COVID-19 patients treated with plasma exchange or tocilizumab. J Zhejiang Univ (Med Sci), 49(2):227-231 (in Chinese).
[60]MaXC, LiangML, DingM, et al., 2020. Extracorporeal membrane oxygenation (ECMO) in critically ill patients with coronavirus disease 2019 (COVID-19) pneumonia and acute respiratory distress syndrome (ARDS). Med Sci Monit, 26:e925364.
[61]Mair-JenkinsJ, Saavedra-CamposM, BaillieJK, et al., 2015. The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis. J Infect Dis, 211(1):80-90.
[62]MenonR, OttoEA, SealfonR, et al., 2020. SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease. Kidney Int, 98(6):1502-1518.
[63]MoradiH, AbbasiS, 2020. Hemoperfusion as a supportive treatment in a COVID-19 patient with late pulmonary thromboembolism: a case report. Int Med Case Rep J, 13:341-345.
[64]NaKR, KimHR, HamY, et al., 2020. Acute kidney injury and kidney damage in COVID-19 patients. J Korean Med Sci, 35(28):e257.
[65]NachtigallI, LengaP, JóźwiakK, et al., 2020. Clinical course and factors associated with outcomes among 1904 patients hospitalized with COVID-19 in Germany: an observational study. Clin Microbiol Infect, 26(12):1663-1669.
[66]NadimMK, ForniLG, MehtaRL, et al., 2020. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol, 16(12):747-764.
[67]Ñamendys-SilvaSA, 2020. ECMO for ARDS due to COVID-19. Heart Lung, 49(4):348-349.
[68]NappLC, KühnC, HoeperMM, et al., 2016. Cannulation strategies for percutaneous extracorporeal membrane oxygenation in adults. Clin Res Cardiol, 105(4):283-296.
[69]PanPH, SongC, LuRL, 2020. The timing of continuous renal replacement therapy in severe COVID-19. Chin J Tuberc Respir Dis, 43(9):721-724 (in Chinese).
[70]ParasherA, 2021. COVID-19: current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J, 97(1147):312-320.
[71]PostA, den DeurwaarderESG, BakkerSJL, et al., 2020. Kidney infarction in patients with COVID-19. Am J Kidney Dis, 76(3):431-435.
[72]PourahmadR, MoazzamiB, RezaeiN, 2020. Efficacy of plasmapheresis and immunoglobulin replacement therapy (IVIG) on patients with COVID-19. SN Compr Clin Med, 2(9):1407-1411.
[73]Ramirez-SandovalJC, Gaytan-ArochaJE, Xolalpa-ChávezP, et al., 2021. Prolonged intermittent renal replacement therapy for acute kidney injury in COVID-19 patients with acute respiratory distress syndrome. Blood Purif, 50(3):355-363.
[74]RampinoT, GregoriniM, PerottiL, et al., 2020. Hemoperfusion with cytosorb as adjuvant therapy in critically ill patients with SARS-CoV2 pneumonia. Blood Purif, 50:566-571.
[75]RECOVERY Collaborative Group, 2021. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. Lancet, 397(10289):2049-2059.
[76]RoncoC, BelomoR, HomelP, et al., 2002. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. EDTNA-ERCA J, 28(S2):7-12.
[77]RoncoC, BagshawSM, BellomoR, et al., 2021. Extracorporeal blood purification and organ support in the critically ill patient during COVID-19 pandemic: expert review and recommendation. Blood Purif, 50(1):17-27.
[78]RothanHA, ByrareddySN, 2020. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun, 109:102433.
[79]SafariS, SalimiA, ZaliA, et al., 2020. Extracorporeal hemoperfusion as a potential therapeutic option for severe COVID-19 patients; a narrative review. Arch Acad Emerg Med, 8(1):e67.
[80]SchefoldJC, von HaehlingS, CorsepiusM, et al., 2007. A novel selective extracorporeal intervention in sepsis. Shock, 28(4):418-425.
[81]SchmidtM, JaberS, ZogheibE, et al., 2018. Feasibility and safety of low-flow extracorporeal CO2 removal managed with a renal replacement platform to enhance lung-protective ventilation of patients with mild-to-moderate ARDS. Crit Care, 22:122.
[82]ShenCG, WangZQ, ZhaoF, et al., 2020. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA, 323(16):1582-1589.
[83]ShiH, ZhouCM, HePH, et al., 2020. Successful treatment with plasma exchange followed by intravenous immunoglobulin in a critically ill patient with COVID-19. Int J Antimicrob Agents, 56(2):105974.
[84]ShiY, WangG, CaiXP, et al., 2020. An overview of COVID-19. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 21(5):343-360.
[85]SmolanderJ, BruchfeldA, 2020. COVID-19 and kidney disease. Lakartidningen, 117:20110 (in Swedish).
[86]StahlK, SchmidtJJ, SeeligerB, et al., 2020a. Effect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock. Crit Care, 24:71.
[87]StahlK, BodeC, DavidS, 2020b. First do no harm—beware the risk of therapeutic plasma exchange in severe COVID-19. Crit Care, 24:363.
[88]TandukarS, PalevskyPM, 2019. Continuous renal replacement therapy: who, when, why, and how. Chest, 155(3):626-638.
[89]The RENAL Replacement Therapy Study Investigators, 2009. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med, 361(17):1627-1638.
[90]The VA/NIH Acute Renal Failure Trial Network, 2008. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med, 359(1):7-20.
[91]TullyRP, HopleyN, LawrenceG, 2020. The successful use of extracorporeal carbon dioxide removal as a rescue therapy in a patient with severe COVID-19 pneumonitis. Anaesth Rep, 8(2):113-115.
[92]VardanjaniAE, RoncoC, RafieiH, et al., 2021. Early hemoperfusion for cytokine removal may contribute to prevention of intubation in patients infected with COVID-19. Blood Purif, 50(2):257-260.
[93]VargaZ, FlammerAJ, SteigerP, et al., 2020. Endothelial cell infection and endotheliitis in COVID-19. Lancet, 395(10234):1417-1418.
[94]VelavanTP, MeyerCG, 2020. The COVID-19 epidemic. Trop Med Int Health, 25(3):278-280.
[95]VillaG, ChelazziC, MorettiniE, et al., 2017. Organ dysfunction during continuous veno-venous high cut-off hemodialysis in patients with septic acute kidney injury: a prospective observational study. PLoS ONE, 12(2):e0172039.
[96]VolbedaM, LondemaM, van MeursM, et al., 2020. A method to improve continuous renal replacement therapy circuit survival time in critically ill coronavirus disease 2019 patients with acute kidney injury. Crit Care Explor, 2(10):e0258.
[97]WangP, ShaJ, MengM, et al., 2020. Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study. J Transl Med, 18:461.
[98]WangY, JiangWW, HeQ, et al., 2020. A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia. Sig Transduct Target Ther, 5:57.
[99]WeidhaseL, HaussigE, HaussigS, et al., 2019. Middle molecule clearance with high cut-off dialyzer versus high-flux dialyzer using continuous veno-venous hemodialysis with regional citrate anticoagulation: a prospective randomized controlled trial. PLoS ONE, 14(4):e0215823.
[100]WuCM, ChenXY, CaiYP, et al., 2020. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med, 180(7):934-943.
[101]WuHJ, LarsenCP, Hernandez-ArroyoCF, et al., 2020. AKI and collapsing glomerulopathy associated with COVID-19 and APOL1 high-risk genotype. J Am Soc Nephrol, 31(8):1688-1695.
[102]WuZ, ZhangQ, YeG, et al., 2021. Structural and physiological changes of the human body upon SARS-CoV-2 infection. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 22(4):310-317.
[103]WuZY, McGooganJM, 2020. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA, 323(13):1239-1242.
[104]XiangHL, SongB, ZhangYY, et al., 2021. The effectiveness of continuous renal replacement therapy in critical COVID-19 patients with cytokine release syndrome: a retrospective, multicenter, descriptive study from Wuhan, China. Aging, 13(7):9243-9252
[105]YangXB, YuY, XuJQ, et al., 2020. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med, 8(5):475-481.
[106]YangY, ShiJ, GeS, et al., 2020. Association between prolonged intermittent renal replacement therapy and all-cause mortality in COVID-19 patients undergoing invasive mechanical ventilation: a retrospective cohort study. Blood Purif, 50(4-5):481-488.
[107]YessayanLT, HeungM, GirardFA, et al., 2021. Deployment of a new CRRT/PIRRT device during the COVID-19 pandemic emergency: organizational challenges and implementation results. Blood Purif, 50(3):390-398.
[108]YiğenoğluTN, UlasT, DalMS, et al., 2020. Extracorporeal blood purification treatment options for COVID-19: the role of immunoadsorption. Transfus Apher Sci, 59(4):102855.
[109]YouB, ZhangYL, LuoGX, et al., 2018. Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns. Crit Care, 22:173.
[110]ZachariahU, NairSC, GoelA, et al., 2020. Targeting raised von Willebrand factor levels and macrophage activation in severe COVID-19: consider low volume plasma exchange and low dose steroid. Thromb Res, 192:2.
[111]ZarbockA, KellumJA, SchmidtC, et al., 2016. Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA, 315(20):2190-2199.
[112]ZhaoJ, CuiW, TianBP, 2020. Efficacy of tocilizumab treatment in severely ill COVID-19 patients. Crit Care, 24:524.
[113]ZhouF, YuT, DuRH, et al., 2020. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet, 395(10229):1054-1062.
[114]ZouH, LiSQ, 2020. ECMO/CRRT combined support in the treatment of critically ill patients with novel coronavirus pneumonia. Eur Heart J-Case Rep, 4(FI1):1-3.
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