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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.2 P.153-157


Analysis of volatile organic compounds in exhaled breath after radiotherapy

Author(s):  Dianlong GE, Xue ZOU, Yajing CHU, Jijuan ZHOU, Wei XU, Yue LIU, Qiangling ZHANG, Yan LU, Lei XIA, Aiyue LI, Chaoqun HUANG, Pei WANG, Chengyin SHEN, Yannan CHU

Affiliation(s):  Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China; more

Corresponding email(s):   xzou@cmpt.ac.cn, 61775618@qq.com

Key Words:  Radiotherapy, Breatht, Volatile organic compounds, GC-MS

Dianlong GE, Xue ZOU, Yajing CHU, Jijuan ZHOU, Wei XU, Yue LIU, Qiangling ZHANG, Yan LU, Lei XIA, Aiyue LI, Chaoqun HUANG, Pei WANG, Chengyin SHEN, Yannan CHU. Analysis of volatile organic compounds in exhaled breath after radiotherapy[J]. Journal of Zhejiang University Science B, 2022, 23(2): 153-157.

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author="Dianlong GE, Xue ZOU, Yajing CHU, Jijuan ZHOU, Wei XU, Yue LIU, Qiangling ZHANG, Yan LU, Lei XIA, Aiyue LI, Chaoqun HUANG, Pei WANG, Chengyin SHEN, Yannan CHU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Analysis of volatile organic compounds in exhaled breath after radiotherapy
%A Dianlong GE
%A Xue ZOU
%A Yajing CHU
%A Jijuan ZHOU
%A Wei XU
%A Yue LIU
%A Qiangling ZHANG
%A Yan LU
%A Lei XIA
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%A Chaoqun HUANG
%A Chengyin SHEN
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%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100447

T1 - Analysis of volatile organic compounds in exhaled breath after radiotherapy
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A1 - Yajing CHU
A1 - Jijuan ZHOU
A1 - Wei XU
A1 - Yue LIU
A1 - Qiangling ZHANG
A1 - Yan LU
A1 - Lei XIA
A1 - Aiyue LI
A1 - Chaoqun HUANG
A1 - Pei WANG
A1 - Chengyin SHEN
A1 - Yannan CHU
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DOI - 10.1631/jzus.B2100447

radiotherapy uses high-energy X-rays or other particles to destroy cancer cells and medical practitioners have used this approach extensively for cancer treatment (Hachadorian et al., 2020). However, it is accompanied by risks because it seriously harms normal cells while killing cancer cells. The side effects can lower cancer patients' quality of life and are very unpredictable due to individual differences (Bentzen, 2006). Therefore, it is essential to assess a patient's body damage after radiotherapy to formulate an individualized recovery treatment plan. Exhaled volatile organic compounds (VOCs) can be changed by radiotherapy and thus used for medical diagnosis (Vaks et al., 2012). During treatment, high-energy X-rays can induce apoptosis; meanwhile, cell membranes are damaged due to lipid peroxidation, converting unsaturated fatty acids into volatile metabolites (Losada-Barreiro and Bravo-Díaz, 2017). At the same time, radiotherapy oxidizes water, resulting in reactive oxygen species (ROS) that can increase the epithelial permeability of pulmonary alveoli, enabling the respiratory system to exhale volatile metabolites (Davidovich et al., 2013; Popa et al., 2020). These exhaled VOCs can be used to monitor body damage caused by radiotherapy.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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