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On-line Access: 2022-02-17

Received: 2021-06-10

Revision Accepted: 2021-09-07

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jianhong ZHOU

https://orcid.org/0000-0001-9829-8076

Jun LIN

https://orcid.org/0000-0002-1370-1872

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.2 P.158-163

http://doi.org/10.1631/jzus.B2100502


Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis


Author(s):  Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN

Affiliation(s):  Department of Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; more

Corresponding email(s):   linjun@zju.edu.cn, zhoujh1117@zju.edu.cn

Key Words:  Ovarian endometriomas, Recurrence, Human telomerase reverse transcriptase, Ki-67, CA125


Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN. Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis[J]. Journal of Zhejiang University Science B, 2022, 23(2): 158-163.

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author="Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN",
journal="Journal of Zhejiang University Science B",
volume="23",
number="2",
pages="158-163",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100502"
}

%0 Journal Article
%T Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
%A Jie LUO
%A Zhimin SONG
%A Tao ZHANG
%A Ketan CHU
%A Jingyi LI
%A Jianhong ZHOU
%A Jun LIN
%J Journal of Zhejiang University SCIENCE B
%V 23
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%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100502

TY - JOUR
T1 - Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
A1 - Jie LUO
A1 - Zhimin SONG
A1 - Tao ZHANG
A1 - Ketan CHU
A1 - Jingyi LI
A1 - Jianhong ZHOU
A1 - Jun LIN
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 2
SP - 158
EP - 163
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100502


Abstract: 
At present, endometriosis remains a worldwide health burden, with the main symptoms of dysmenorrhea, chronic pelvic pain, and infertility, markedly reducing the quality of life (de Ziegler et al., 2010). Although there is no proof that the disease is associated with high mortality, this disorder can significantly contribute to the deterioration of women's general well-being (McPeak et al., 2018). The main current treatment for endometriosis is surgery to remove endometriotic lesions; however, the recurrence rate following surgical treatment is as high as 21.5% at two years and 40.0%‍–‍50.0% at five years post-surgery (Koga et al., 2015). To prevent recurrence, adjuvant treatment with drugs after surgery is recommended to prolong relapse-free intervals. However, it is inconvenient for patients to continuously use such medications in terms of adverse effects and cost (Turk, 2002).

异位内膜中h-TERT和Ki-67的表达上调与子宫内膜异位症复发相关

目的:探讨人类端粒酶逆转录酶(h-TERT)和Ki-67与子宫内膜异位症复发的相关性。
创新点:第一次将h-TERT和Ki-67联合表达水平可作为卵巢子宫内膜异位症复发的有用预测标志物。
方法:收集30例术后30个月复发的卵巢子宫内膜异位症患者、30例术后30个月未复发的卵巢子宫内膜异位症患者和30例对照组的子宫内膜异位症组织样本。采用免疫组织化学方法检测异位子宫内膜组织中h-TERT和Ki-67的表达。
结论:h-TERT和Ki-67联合表达水平可作为卵巢子宫内膜异位症复发的有用预测标志物,子宫内膜h-TERT过度表达以及术后血清CA125水平升高可能在卵巢子宫内膜异位症复发中起重要作用。

关键词:卵巢子宫内膜异位症;复发;人端粒酶逆转录酶(h-TERT);Ki-67;CA125

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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