Full Text:   <1076>

Summary:  <225>

Suppl. Mater.: 

CLC number: 

On-line Access: 2022-02-17

Received: 2021-06-10

Revision Accepted: 2021-09-07

Crosschecked: 0000-00-00

Cited: 0

Clicked: 1871

Citations:  Bibtex RefMan EndNote GB/T7714


Jianhong ZHOU




-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.2 P.158-163


Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis

Author(s):  Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN

Affiliation(s):  Department of Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; more

Corresponding email(s):   linjun@zju.edu.cn, zhoujh1117@zju.edu.cn

Key Words:  Ovarian endometriomas, Recurrence, Human telomerase reverse transcriptase, Ki-67, CA125

Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN. Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis[J]. Journal of Zhejiang University Science B, 2022, 23(2): 158-163.

@article{title="Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis",
author="Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
%A Jie LUO
%A Zhimin SONG
%A Ketan CHU
%A Jingyi LI
%A Jianhong ZHOU
%A Jun LIN
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 2
%P 158-163
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100502

T1 - Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
A1 - Jie LUO
A1 - Zhimin SONG
A1 - Tao ZHANG
A1 - Ketan CHU
A1 - Jingyi LI
A1 - Jianhong ZHOU
A1 - Jun LIN
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 2
SP - 158
EP - 163
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100502

At present, endometriosis remains a worldwide health burden, with the main symptoms of dysmenorrhea, chronic pelvic pain, and infertility, markedly reducing the quality of life (de Ziegler et al., 2010). Although there is no proof that the disease is associated with high mortality, this disorder can significantly contribute to the deterioration of women's general well-being (McPeak et al., 2018). The main current treatment for endometriosis is surgery to remove endometriotic lesions; however, the recurrence rate following surgical treatment is as high as 21.5% at two years and 40.0%‍–‍50.0% at five years post-surgery (Koga et al., 2015). To prevent recurrence, adjuvant treatment with drugs after surgery is recommended to prolong relapse-free intervals. However, it is inconvenient for patients to continuously use such medications in terms of adverse effects and cost (Turk, 2002).




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]AlnafakhRAA, AdisheshM, ButtonL, et al., 2019. Telomerase and telomeres in endometrial cancer. Front Oncol, 9:344.

[2]BozdagG, 2015. Recurrence of endometriosis: risk factors, mechanisms and biomarkers. Women’s Health, 11(5):693-699.

[3]BubendorfL, SauterG, MochH, et al., 1996. Ki67 labelling index: an independent predictor of progression in prostate cancer treated by radical prostatectomy. J Pathol, 178(4):437-441.

[4]CeccaroniM, BounousVE, ClariziaR, et al., 2019. Recurrent endometriosis: a battle against an unknown enemy. Eur J Contracept Reprod Health Care, 24(6):464-474.

[5]ChapronC, MarcellinL, BorgheseB, et al., 2019. Rethinking mechanisms, diagnosis and management of endometriosis. Nat Rev Endocrinol, 15(11):666-682.

[6]ChiangHJ, LinPY, HuangFJ, et al., 2015. The impact of previous ovarian surgery on ovarian reserve in patients with endometriosis. BMC Women’s Health, 15:74.

[7]de ZieglerD, BorgheseB, ChapronC, 2010. Endometriosis and infertility: pathophysiology and management. Lancet, 376(9742):730-738.

[8]DingL, ZhouYX, HeC, et al., 2020. Elevated CA125 levels are associated with adverse clinical outcomes in acute pancreatitis: a propensity score-matched study. Pancreatology, 20(5):789-794.

[9]GreeneAD, LangSA, KendziorskiJA, et al., 2016. Endometriosis: where are we and where are we going? Reproduction, 152(3):R63-R78.

[10]HanegeBY, ÇekıçSG, AtaB, 2019. Endometrioma and ovarian reserve: effects of endometriomata per se and its surgical treatment on the ovarian reserve. Facts Views Vis Obgyn, 11(2):151-157.

[11]HannenR, BartschJW, 2018. Essential roles of telomerase reverse transcriptase hTERT in cancer stemness and metastasis. FEBS Lett, 592(12):2023-2031.

[12]HuCJ, NiZH, LiBS, et al., 2017. hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation. Gut, 66(1):31-42.

[13]KajiyamaH, SuzukiS, YoshiharaM, et al., 2019. Endometriosis and cancer. Free Radic Biol Med, 133:186-192.

[14]KalaitzopoulosDR, MitsopoulouA, IliopoulouSM, et al., 2020. Association between endometriosis and gynecological cancers: a critical review of the literature. Arch Gynecol Obstet, 301(2):355-367.

[15]KogaK, TakamuraM, FujiiT, et al., 2015. Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis. Fertil Steril, 104(4):793-801.

[16]LaganàAS, GarzonS, GötteM, et al., 2019. The pathogenesis of endometriosis: molecular and cell biology insights. Int J Mol Sci, 20(22):5615.

[17]LiCH, WangCH, 2021. LG-ESSs and HG-ESSs: underlying molecular alterations and potential therapeutic strategies. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 22(8):633-646.

[18]LiLT, JiangG, ChenQ, et al., 2015. Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep, 11(3):1566-1572.

[19]LiXY, ChaoXP, LengJH, et al., 2019. Risk factors for postoperative recurrence of ovarian endometriosis: long-term follow-up of 358 women. J Ovarian Res, 12:79.

[20]LiY, LiRQ, OuyangNY, et al., 2019. Investigating the impact of local inflammation on granulosa cells and follicular development in women with ovarian endometriosis. Fertil Steril, 112(5):882-891.e1.

[21]LiuSP, XinWJ, TangXY, et al., 2020. LncRNA H19 overexpression in endometriosis and its utility as a novel biomarker for predicting recurrence. Reprod Sci, 27(9):1687-1697.

[22]McPeakAE, AllaireC, WilliamsC, et al., 2018. Pain catastrophizing and pain health-related quality-of-life in endometriosis. Clin J Pain, 34(4):349-356.

[23]MillerI, MinMW, YangC, et al., 2018. Ki67 is a graded rather than a binary marker of proliferation versus quiescence. Cell Rep, 24(5):1105-1112.e5.

[24]ParkJS, LeeJH, KimM, et al., 2009. Endometrium from women with endometriosis shows increased proliferation activity. Fertil Steril, 92(4):1246-1249.

[25]PooleJC, AndrewsLG, TollefsbolTO, 2001. Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene, 269(1-2):1-12.

[26]RollaE, 2019. Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment. F1000Research, 8:529.

[27]SakamotoY, HaradaT, HorieS, et al., 2003. Tumor necrosis factor-α-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-κB activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression. J Clin Endocrinol Metab, 88(2):730-735.

[28]SocolovR, SocolovD, SindilarA, et al., 2017. An update on the biological markers of endometriosis. Minerva Ginecol, 69(5):462-467.

[29]TurkDC, 2002. Clinical effectiveness and cost-effectiveness of treatments for patients with chronic pain. Clin J Pain, 18(6):355-365.

[30]VercelliniP, ViganòP, SomiglianaE, et al., 2014. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol, 10(5):261-275.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE