Full Text:   <1183>

Summary:  <650>

Suppl. Mater.: 

CLC number: 

On-line Access: 2021-12-14

Received: 2021-02-28

Revision Accepted: 2021-08-23

Crosschecked: 0000-00-00

Cited: 0

Clicked: 2042

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Armando ZEPEDA-BASTIDA

https://orcid.org/0000-0003-0572-5206

Jaime ARELLANES-ROBLEDO

https://orcid.org/0000-0001-7363-4870

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.12 P.1045-1052

http://doi.org/10.1631/jzus.B2100201


Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo


Author(s):  Armando ZEPEDA-BASTIDA, Juan OCAMPO-LPEZ, Brisa Rodope ALARCN-SNCHEZ, Osiris Germn IDELFONSO-GARCA, Sandra ROSAS-MADRIGAL, Diana Ivette APARICIO-BAUTISTA, Julio Isael PREZ-CARREN, Sal VILLA-TREVIO, Jaime ARELLANES-ROBLEDO

Affiliation(s):  Laboratory of Liver Diseases, National Institute of Genomic Medicine-INMEGEN, CDMX 14610, Mexico; more

Corresponding email(s):   jarellanes@inmegen.gob.mx, azepeda@uaeh.edu.mx

Key Words:  Diethylnitrosamine, Hepatocellular carcinoma, Liver cancer prevention, Proliferation inhibition


Armando ZEPEDA-BASTIDA, Juan OCAMPO-LPEZ, Brisa Rodope ALARCN-SNCHEZ, Osiris Germn IDELFONSO-GARCA, Sandra ROSAS-MADRIGAL, Diana Ivette APARICIO-BAUTISTA, Julio Isael PREZ-CARREN, Sal VILLA-TREVIO, Jaime ARELLANES-ROBLEDO. Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo[J]. Journal of Zhejiang University Science B, 2021, 22(12): 1045-1052.

@article{title="Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo",
author="Armando ZEPEDA-BASTIDA, Juan OCAMPO-LPEZ, Brisa Rodope ALARCN-SNCHEZ, Osiris Germn IDELFONSO-GARCA, Sandra ROSAS-MADRIGAL, Diana Ivette APARICIO-BAUTISTA, Julio Isael PREZ-CARREN, Sal VILLA-TREVIO, Jaime ARELLANES-ROBLEDO",
journal="Journal of Zhejiang University Science B",
volume="22",
number="12",
pages="1045-1052",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100201"
}

%0 Journal Article
%T Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo
%A Armando ZEPEDA-BASTIDA
%A Juan OCAMPO-LPEZ
%A Brisa Rodope ALARCN-SNCHEZ
%A Osiris Germn IDELFONSO-GARCA
%A Sandra ROSAS-MADRIGAL
%A Diana Ivette APARICIO-BAUTISTA
%A Julio Isael PREZ-CARREN
%A Sal VILLA-TREVIO
%A Jaime ARELLANES-ROBLEDO
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 12
%P 1045-1052
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100201

TY - JOUR
T1 - Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo
A1 - Armando ZEPEDA-BASTIDA
A1 - Juan OCAMPO-LPEZ
A1 - Brisa Rodope ALARCN-SNCHEZ
A1 - Osiris Germn IDELFONSO-GARCA
A1 - Sandra ROSAS-MADRIGAL
A1 - Diana Ivette APARICIO-BAUTISTA
A1 - Julio Isael PREZ-CARREN
A1 - Sal VILLA-TREVIO
A1 - Jaime ARELLANES-ROBLEDO
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 12
SP - 1045
EP - 1052
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100201


Abstract: 
hepatocellular carcinoma (HCC), which is the most frequent primary liver malignancy, is ranked as the sixth most common cancer and the third leading cause of cancer-related deaths worldwide, with its incidence expected to continue rising. One of the reasons is that most patients are diagnosed at an advanced stage when therapeutic options are ineffective. The development of HCC is attributed to a chronic exposition to either one or a combination of low amounts of different hepatotoxins, such as in hepatitis virus infection, alcohol consumption, aflatoxin from contaminated foods, metabolic factors, and exposure to chemical carcinogens from tobacco smoke (Forner et al., 2018). Integrative studies combining exome sequencing, transcriptome analysis, and the genomic characterization of HCC have shown that these etiological factors may raise the frequency of particular genetic alterations, resulting in intra-tumor heterogeneity that presents a huge challenge for treatment. For example, mutations in the catenin β-1 (CTNNB1) gene (a proto-oncogene in the WNT signaling pathway that encodes the β‍-catenin transcription factor) are strongly associated with alcohol-related HCC, whereas mutations in the telomerase reverse transcriptase (TERT) promoter and tumor protein p53 (TP53) genes are the most commonly observed in hepatitis B virus (HBV)‍-associated HCC (Calderaro et al., 2017; Cancer Genome Atlas Research Network, 2017). The above findings emphasize the molecular diversity of HCC and the associations of different etiologies with distinct mechanisms in HCC progression. Consequently, prevention strategies are still attractive for HCC management.

黄粉虫幼虫和蛹期的水提取物抑制体内早期肝癌发生

概要:肝细胞癌(HCC)具有复杂的肿瘤内异质性,这会导致治疗失败。传统医学和实验研究表明,食用昆虫具有治疗包括HCC在内的不同疾病的潜力。我们在获得黄粉虫水提物后,通过组织病理学、免疫组织化学、蛋白质印迹和影像学分析确定其有效成分,并比较黄粉虫三个生命阶段(包括幼虫、蛹和成虫)的水提物对二乙基亚硝胺(DEN)诱导的小鼠早期HCC的影响。结果表明,与黄粉虫蛹的水提取物相比,幼虫水提物能更显着地通过抗增殖机制来抑制早期肝癌的发生。

关键词:二乙基亚硝胺;肝细胞癌;肝癌预防;增殖抑制

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Arellanes-RobledoJ, Márquez-RosadoL, Pérez-CarreónJI, et al., 2006. Celecoxib induces regression of putative preneoplastic lesions in rat liver. Anticancer Res, 26(2A):1271-1280.

[2]CalderaroJ, CouchyG, ImbeaudS, et al., 2017. Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. J Hepatol, 67(4):727-738.

[3]Cancer Genome Atlas Research Network, 2017. Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell, 169(7):1327-1341.e23.

[4]FornerA, ReigM, BruixJ, 2018. Hepatocellular carcinoma. Lancet, 391(10127):1301-1314.

[5]Fuentes-HernándezS, Alarcón-SánchezBR, Guerrero-EscaleraD, et al., 2019. Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. Toxicol Appl Pharmacol, 378:114611.

[6]GaoY, WangD, XuML, et al., 2018. Toxicological characteristics of edible insects in China: a historical review. Food Chem Toxicol, 119:237-251.

[7]HanahanD, WeinbergRA, 2011. Hallmarks of cancer: the next generation. Cell, 144(5):646-674.

[8]LecarpentierY, SchusslerO, HébertJL, et al., 2019. Multiple targets of the canonical WNT/β‍-catenin signaling in cancers. Front Oncol, 9:1248.

[9]NongoniermaAB, FitzgeraldRJ, 2017. Unlocking the biological potential of proteins from edible insects through enzymatic hydrolysis: a review. Innov Food Sci Emerg Technol, 43:239-252.

[10]RatcliffeNA, MelloCB, GarciaES, et al., 2011. Insect natural products and processes: new treatments for human disease. Insect Biochem Mol Biol, 41(10):747-769.

[11]RolffJ, JohnstonPR, ReynoldsS, 2019. Complete metamorphosis of insects. Philos Trans Roy Soc B Biol Sci, 374(1783):20190063.

[12]TettamantiG, GrimaldiA, CasartelliM, et al., 2007. Programmed cell death and stem cell differentiation are responsible for midgut replacement in Heliothis virescens during prepupal instar. Cell Tissue Res, 330(2):345-359.

[13]UetaT, IkeguchiM, HirookaY, et al., 2002. β‍-Catenin and cyclin D1 expression in human hepatocellular carcinoma. Oncol Rep, 9(6):1197-1203.

[14]WuRA, DingQZ, LuHJ, et al., 2020. Caspase 3-mediated cytotoxicity of mealworm larvae (Tenebrio molitor) oil extract against human hepatocellular carcinoma and colorectal adenocarcinoma. J Ethnopharmacol, 250:112438.

[15]YooYC, ShinBH, HongJH, et al., 2007. Isolation of fatty acids with anticancer activity from Protaetia brevitarsis larva. Arch Pharm Res, 30(3):361-365.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE