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On-line Access: 2022-07-06
Received: 2021-11-15
Revision Accepted: 2022-03-21
Crosschecked: 2022-07-06
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ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma
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Lu XIA, Hexin LIN, Yanming ZHOU, Jiabian LIAN. ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma[J]. Journal of Zhejiang University Science B, 2022, 23(7): 587-596.
@article{title="ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma",
author="Lu XIA, Hexin LIN, Yanming ZHOU, Jiabian LIAN",
journal="Journal of Zhejiang University Science B",
volume="23",
number="7",
pages="587-596",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100939"
}
%0 Journal Article
%T ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma
%A Lu XIA
%A Hexin LIN
%A Yanming ZHOU
%A Jiabian LIAN
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 7
%P 587-596
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100939
TY - JOUR
T1 - ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma
A1 - Lu XIA
A1 - Hexin LIN
A1 - Yanming ZHOU
A1 - Jiabian LIAN
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 7
SP - 587
EP - 596
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100939
Abstract: The epidermal cell differentiation regulator zinc Finger Protein 750 (ZNF750) is a transcription factor containing the Cys2His2 (C2H2) domain, the zinc finger structure of which is located at the N-terminal 25–46 amino acids of ZNF750. It can promote the expression of differentiation-related factors while inhibiting the expression of progenitor cell-related genes. ZNF750 is directly regulated by p63 (encoded by the TP63 gene, belonging to the TP53 superfamily). The Krüppel-like factor 4 (KLF4), repressor element-1 (RE-1)-silencing transcription factor (REST) corepressor 1 (RCOR1), lysine demethylase 1A (KDM1A), and C-terminal-binding protein 1/2 (CTBP1/2) chromatin regulators cooperate with ZNF750 to repress epidermal progenitor genes and activate the expression of epidermal terminal differentiation genes (
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