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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.7 P.529-546


Co-regulation of circadian clock genes and microRNAs in bone metabolism

Author(s):  Tingting LI, Shihua ZHANG, Yuxuan YANG, Lingli ZHANG, Yu YUAN, Jun ZOU

Affiliation(s):  School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China; more

Corresponding email(s):   junzou@sus.edu.cn, yuanyumail@126.com

Key Words:  Circadian rhythm, Circadian clock gene, MicroRNAs, Bone metabolism

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Tingting LI, Shihua ZHANG, Yuxuan YANG, Lingli ZHANG, Yu YUAN, Jun ZOU. Co-regulation of circadian clock genes and microRNAs in bone metabolism[J]. Journal of Zhejiang University Science B, 2022, 23(7): 529-546.

@article{title="Co-regulation of circadian clock genes and microRNAs in bone metabolism",
author="Tingting LI, Shihua ZHANG, Yuxuan YANG, Lingli ZHANG, Yu YUAN, Jun ZOU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Co-regulation of circadian clock genes and microRNAs in bone metabolism
%A Tingting LI
%A Shihua ZHANG
%A Yuxuan YANG
%A Lingli ZHANG
%A Jun ZOU
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 7
%P 529-546
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100958

T1 - Co-regulation of circadian clock genes and microRNAs in bone metabolism
A1 - Tingting LI
A1 - Shihua ZHANG
A1 - Yuxuan YANG
A1 - Lingli ZHANG
A1 - Yu YUAN
A1 - Jun ZOU
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 7
SP - 529
EP - 546
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100958

Mammalian bone is constantly metabolized from the embryonic stage, and the maintenance of bone health depends on the dynamic balance between bone resorption and bone formation, mediated by osteoclasts and osteoblasts. It is widely recognized that circadian clock genes can regulate bone metabolism. In recent years, the regulation of bone metabolism by non-coding RNAs has become a hotspot of research. microRNAs can participate in bone catabolism and anabolism by targeting key factors related to bone metabolism, including circadian clock genes. However, research in this field has been conducted only in recent years and the mechanisms involved are not yet well established. Recent studies have focused on how to target circadian clock genes to treat some diseases, such as autoimmune diseases, but few have focused on the co-regulation of circadian clock genes and microRNAs in bone metabolic diseases. Therefore, in this paper we review the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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