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CLC number: R392.11

On-line Access: 2013-01-08

Received: 2012-10-30

Revision Accepted: 2012-11-07

Crosschecked: 2012-12-10

Cited: 18

Clicked: 4792

Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.1 P.1-7


MicroRNAs in the regulation of immune response against infections

Author(s):  Yue Zhang, Ying-ke Li

Affiliation(s):  Department of General Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120, China; more

Corresponding email(s):   magiczhangyue@yahoo.com.cn

Key Words:  MicroRNA, Immune regulation, Pathogen, Infection

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Yue Zhang, Ying-ke Li. MicroRNAs in the regulation of immune response against infections[J]. Journal of Zhejiang University Science B, 2013, 14(1): 1-7.

@article{title="MicroRNAs in the regulation of immune response against infections",
author="Yue Zhang, Ying-ke Li",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T MicroRNAs in the regulation of immune response against infections
%A Yue Zhang
%A Ying-ke Li
%J Journal of Zhejiang University SCIENCE B
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%N 1
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%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200292

T1 - MicroRNAs in the regulation of immune response against infections
A1 - Yue Zhang
A1 - Ying-ke Li
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 1
SP - 1
EP - 7
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200292

Innate immunity is considered to provide the initial defense against infections by viruses, bacteria, fungi, and protozoa. Detection of the signature molecules of invading pathogens by front-line defense cells via various germline-encoded pattern recognition receptors (PRRs) is needed to activate intracellular signaling cascades that lead to transcriptional expression of inflammatory mediators to coordinate the elimination of pathogens and infected cells. To maintain a fine balance between protective immunity and inflammatory pathology upon infection, the innate signaling pathways in the host need to be tightly regulated. microRNAs (miRNAs), a new class of small non-coding RNAs, have been recently shown to be potent modulators that function at post-transcriptional levels. Accumulating evidence demonstrates that the involvement of microorganism-encoded and host miRNAs might play instructive roles in the immune response upon infection. Here, we discuss the current knowledge of miRNAs in the regulation of immune response against infections.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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