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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2200054


Clinical and immune response characteristics among vaccinated persons infected with SARS-CoV-2 delta variant: a retrospective study


Author(s):  Cunjin WANG, Yong LI, Yuchen PAN, Luojing ZHOU, Xi ZHANG, Yan WEI, Fang GUO, Yusheng SHU, and Ju GAO

Affiliation(s):  Department of Anesthesiology, Northern Jiangsu People's Hospital, Yangzhou, 225001, China; more

Corresponding email(s):   shuyusheng65@163.com, gaoju_003@163.com

Key Words:  SARS-CoV-2, Delta variant, Vaccine, Hospitalization, Immune response


Cunjin WANG, Yong LI, Yuchen PAN, Luojing ZHOU, Xi ZHANG, Yan WEI, Fang GUO, Yusheng SHU, and Ju GAO. Clinical and immune response characteristics among vaccinated persons infected with SARS-CoV-2 delta variant: a retrospective study[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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%T Clinical and immune response characteristics among vaccinated persons infected with SARS-CoV-2 delta variant: a retrospective study
%A Cunjin WANG
%A Yong LI
%A Yuchen PAN
%A Luojing ZHOU
%A Xi ZHANG
%A Yan WEI
%A Fang GUO
%A Yusheng SHU
%A and Ju GAO
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%D 1998
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A1 - Cunjin WANG
A1 - Yong LI
A1 - Yuchen PAN
A1 - Luojing ZHOU
A1 - Xi ZHANG
A1 - Yan WEI
A1 - Fang GUO
A1 - Yusheng SHU
A1 - and Ju GAO
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VL - -1
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Y1 - 1998
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2200054


Abstract: 
This study aimed to observe the clinical and immune response characteristics of vaccinated persons infected with the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Yangzhou, China. Methods: We extracted the medical data of 129 patients with delta-variant infection who were admitted to Northern Jiangsu People’s Hospital between August and September, 2021. The patients were grouped according to the number of vaccine doses received into an unvaccinated group, a one-dose group, and a two-dose group. The vaccine used was SARS-CoV-2 inactivated vaccine developed by Sinovac. We retrospectively analyzed the patients’ epidemiological, clinical, laboratory, and imaging data. Results: Almost all patients with delta-variant infection in Yangzhou were elderly, and patients with severe/critical illness were over 70 years of age. The rates of severe/critical illness (P = 0.006), fever (P = 0.025), and dyspnea (P = 0.045) were lower in the two-dose group than in the unvaccinated group. Compared to the unvaccinated group, the two-dose group showed significantly higher lymphocyte counts and significantly lower levels of C-reactive protein, interleukin-6, and D-Dimer during hospitalization and a significantly higher positive rate of IgG antibodies at admission (all P < 0.05). The cumulative probabilities of hospital discharge and negative virus conversion were also higher in the two-dose group than the unvaccinated group (P < 0.05). Conclusions: Two doses of the SARS-CoV-2 inactivated vaccine were highly effective at limiting symptomatic disease and reducing immune response, while a single dose did not seem to be effective.

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