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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2200107


Use of folic acid nanosensors with excellent photostability for hybrid imaging


Author(s):  Denis KUZNETSOV, Sergey DEZHUROV, Dmitri KRYLSKY, Valery NOVIKOV, Valery NESCHISLIAEV, Anastasia KUZNETSOVA

Affiliation(s):  G.N. Gabrichevsky Scientific and Research Institute of Epidemiology and Microbiology: Gabrichevsky Scientific and Research Institute of Epidemiology and Microbiology, 10, Admirala Makarova str., Moscow, 125212, Russian Federation; more

Corresponding email(s):   denis.pfa@gmail.com

Key Words:  Stomach cancer, Hybrid imaging, Nanosensors, Photostability, Folic acid


Denis KUZNETSOV, Sergey DEZHUROV, Dmitri KRYLSKY, Valery NOVIKOV, Valery NESCHISLIAEV, Anastasia KUZNETSOVA. Use of folic acid nanosensors with excellent photostability for hybrid imaging[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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%A Sergey DEZHUROV
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%A Valery NESCHISLIAEV
%A Anastasia KUZNETSOVA
%J Journal of Zhejiang University SCIENCE B
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A1 - Valery NESCHISLIAEV
A1 - Anastasia KUZNETSOVA
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Abstract: 
Sentinel lymph node (SLN) mapping and tumour-boundary delineation play a key role in cancer surgery, as they have great potential to reduce surgical intervention and increase relapse-free survival rates of patients. The autofluorescence method (AFI) can improve the efficiency of tumour delineation and optimize the scope of surgical intervention, but there are still no fluorescent drugs that can be used with such a method to form a hybrid imaging technique. Another problem is bleaching when fluorescent dyes are conjugated with folic acid. This study reports, for the first time, nanosensors with excellent photostability and compatibility with endoscopes for AFI, which makes simultaneous hybrid imaging possible. After functionalization of the quantum dot surfaces, we found that they bound effectively to MCF-7 cancer cells. The diagnostic value of simultaneous hybrid imaging using common AFI equipment in delineating tumour boundaries and mapping SLN can reduce the cost of diagnosis and increase its reliability.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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