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On-line Access: 2022-06-16

Received: 2022-03-03

Revision Accepted: 2022-05-22

Crosschecked: 2022-09-16

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.9 P.784-790


Use of folic acid nanosensors with excellent photostability for hybrid imaging

Author(s):  Denis KUZNETSOV, Sergey DEZHUROV, Dmitri KRYLSKY, Valery NOVIKOV, Valery NESCHISLIAEV, Anastasiia KUZNETSOVA

Affiliation(s):  GN. Gabrichevsky Scientific and Research Institute of Epidemiology and Microbiology, Moscow 125212, Russia; more

Corresponding email(s):   denis.pfa@gmail.com

Key Words:  Stomach cancer, Hybrid imaging, Nanosensors, Photostability, Folic acid

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Denis KUZNETSOV, Sergey DEZHUROV, Dmitri KRYLSKY, Valery NOVIKOV, Valery NESCHISLIAEV, Anastasiia KUZNETSOVA. Use of folic acid nanosensors with excellent photostability for hybrid imaging[J]. Journal of Zhejiang University Science B, 2022, 23(9): 784-790.

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author="Denis KUZNETSOV, Sergey DEZHUROV, Dmitri KRYLSKY, Valery NOVIKOV, Valery NESCHISLIAEV, Anastasiia KUZNETSOVA",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Use of folic acid nanosensors with excellent photostability for hybrid imaging
%A Anastasiia KUZNETSOVA
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 9
%P 784-790
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200107

T1 - Use of folic acid nanosensors with excellent photostability for hybrid imaging
A1 - Sergey DEZHUROV
A1 - Dmitri KRYLSKY
A1 - Valery NOVIKOV
A1 - Anastasiia KUZNETSOVA
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 9
SP - 784
EP - 790
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200107

Sentinel lymph node (SLN) mapping and tumor-boundary delineation play a key role in cancer surgery, as they have great potential to reduce surgical intervention and increase relapse-free survival rates of patients. The autofluorescence imaging (AFI) method can improve the efficiency of tumor delineation and optimize the scope of surgical intervention, but there are still no fluorescent drugs that can be used with such a method to form a hybrid imaging technique. Another problem is bleaching when fluorescent dyes are conjugated with folic acid. This study reports, for the first time, nanosensors with excellent photostability and compatibility with endoscopes for AFI, which makes simultaneous hybrid imaging possible. After functionalization of the quantum dot (QD) surfaces, we found that they bound effectively to MCF-7 cancer cells. The diagnostic value of simultaneous hybrid imaging using common AFI equipment in delineating tumor boundaries and mapping SLN can reduce the cost of diagnosis and increase its reliability.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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