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CLC number: Q2; TN2; R73

On-line Access: 2010-06-02

Received: 2009-11-27

Revision Accepted: 2010-03-09

Crosschecked: 2010-05-06

Cited: 10

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.6 P.417-422

http://doi.org/10.1631/jzus.B0910731


Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging


Author(s):  Li-li Chen, Li Jiang, Ya-lun Wang, Jun Qian, Sailing He

Affiliation(s):  Centre for Optical and Electromagnetic Research, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310058, China, Department of Electromagnetic Engineering, School of Electrical Engineering, Royal Institute of Technology, S-100 44 Stockholm, Sweden

Corresponding email(s):   qianjun@coer.zju.edu.cn

Key Words:  Gold nanorods, Polyelectrolyte, Scattering, Raman, Cancer cell imaging


Li-li Chen, Li Jiang, Ya-lun Wang, Jun Qian, Sailing He. Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging[J]. Journal of Zhejiang University Science B, 2010, 11(6): 417-422.

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author="Li-li Chen, Li Jiang, Ya-lun Wang, Jun Qian, Sailing He",
journal="Journal of Zhejiang University Science B",
volume="11",
number="6",
pages="417-422",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0910731"
}

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%T Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging
%A Li-li Chen
%A Li Jiang
%A Ya-lun Wang
%A Jun Qian
%A Sailing He
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 6
%P 417-422
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0910731

TY - JOUR
T1 - Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging
A1 - Li-li Chen
A1 - Li Jiang
A1 - Ya-lun Wang
A1 - Jun Qian
A1 - Sailing He
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 6
SP - 417
EP - 422
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0910731


Abstract: 
We report the application of multilayered polyelectrolyte-coated gold nanorods (GNRs) as multifunctional optical contrast agents for cancer cell imaging. The surface modification of GNRs improves their chemical stability and facilitates them to be taken up by cancer cells through electrostatic interaction. The unique longitudinal surface plasmon resonance property of GNRs makes them suitable as both “scattering contrast agents” and “raman contrast agents”. In our experiments, the staining of GNRs in cells was further confirmed by dark field microscopy and raman microscopy. Our experiment results indicated that GNRs have great potential as multifunctional “optical contrast agents” for future in vivo animal imaging.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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