CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2023-03-13
Cited: 0
Clicked: 1577
Citations: Bibtex RefMan EndNote GB/T7714
Yi LI, Wenyan SHE, Xiaoran XU, Yixin LIU, Xinyu WANG, Sheng TIAN, Shiyi LI, Miao WANG, Chaochao YU, Pan LIU, Tianhe HUANG, Yongchang WEI. AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer[J]. Journal of Zhejiang University Science B, 2023, 24(3): 232-247.
@article{title="AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer",
author="Yi LI, Wenyan SHE, Xiaoran XU, Yixin LIU, Xinyu WANG, Sheng TIAN, Shiyi LI, Miao WANG, Chaochao YU, Pan LIU, Tianhe HUANG, Yongchang WEI",
journal="Journal of Zhejiang University Science B",
volume="24",
number="3",
pages="232-247",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200351"
}
%0 Journal Article
%T AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer
%A Yi LI
%A Wenyan SHE
%A Xiaoran XU
%A Yixin LIU
%A Xinyu WANG
%A Sheng TIAN
%A Shiyi LI
%A Miao WANG
%A Chaochao YU
%A Pan LIU
%A Tianhe HUANG
%A Yongchang WEI
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 3
%P 232-247
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200351
TY - JOUR
T1 - AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer
A1 - Yi LI
A1 - Wenyan SHE
A1 - Xiaoran XU
A1 - Yixin LIU
A1 - Xinyu WANG
A1 - Sheng TIAN
A1 - Shiyi LI
A1 - Miao WANG
A1 - Chaochao YU
A1 - Pan LIU
A1 - Tianhe HUANG
A1 - Yongchang WEI
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 3
SP - 232
EP - 247
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200351
Abstract: Drastic surges in intracellular reactive oxygen species (ROS) induce cell apoptosis, while most chemotherapy drugs lead to the accumulation of ROS. Here, we constructed an organic compound, arsenical N-;(4-(1,3,2-dithiarsinan-2-yl)phenyl)acrylamide (AAZ2), which could prompt the ROS to trigger mitochondrial-dependent apoptosis in gastric cancer (GC). Mechanistically, by targeting pyruvate dehydrogenase kinase 1 (PDK1), AAZ2 caused metabolism alteration and the imbalance of redox homeostasis, followed by the inhibition of phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway and leading to the activation of B-cell lymphoma 2 (Bcl2)/Bcl2-associated X (Bax)/caspase-9 (Cas9)/Cas3 cascades. Importantly, our in vivo data demonstrated that AAZ2 could inhibit the growth of GC xenograft. Overall, our data suggested that AAZ2 could contribute to metabolic abnormalities, leading to mitochondrial-dependent apoptosis by targeting PDK1 in GC.
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