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On-line Access: 2022-11-15

Received: 2022-04-21

Revision Accepted: 2022-07-22

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.11 P.943-956


Combination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy

Author(s):  Yunlong CHENG, Shu LIAN, Shuhui LI, Yusheng LU, Jie WANG, Xiaoxiao DENG, Shengyi ZHAI, Lee JIA

Affiliation(s):  Fujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, College of Materials and Chemical Engineering, Minjiang University, Fuzhou 350108, China; more

Corresponding email(s):   cmapcjia1234@163.com, jiali@fzu.edu.cn

Key Words:  Cancer prevention, Cancer metastases, Selenium (Se), Combination of drugs, Nutrition

Yunlong CHENG, Shu LIAN, Shuhui LI, Yusheng LU, Jie WANG, Xiaoxiao DENG, Shengyi ZHAI, Lee JIA. Combination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy[J]. Journal of Zhejiang University Science B, 2022, 23(11): 943-956.

@article{title="Combination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy",
author="Yunlong CHENG, Shu LIAN, Shuhui LI, Yusheng LU, Jie WANG, Xiaoxiao DENG, Shengyi ZHAI, Lee JIA",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Combination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy
%A Yunlong CHENG
%A Shuhui LI
%A Yusheng LU
%A Xiaoxiao DENG
%A Shengyi ZHAI
%A Lee JIA
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 11
%P 943-956
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200232

T1 - Combination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy
A1 - Yunlong CHENG
A1 - Shu LIAN
A1 - Shuhui LI
A1 - Yusheng LU
A1 - Jie WANG
A1 - Xiaoxiao DENG
A1 - Shengyi ZHAI
A1 - Lee JIA
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 11
SP - 943
EP - 956
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200232

ObjectivePrimary tumor treatment through surgical resection and adjuvant therapy has been extensively studied, but there is a lack of effective strategies and drugs for the treatment of tumor metastases. Here, we describe a functional product based on a combination of compounds, which can be used as an adjuvant therapy and has well-known mechanisms for inhibiting cancer metastases, improving anti-cancer treatment, and enhancing immunity and antioxidant capacity. Our designed combination, named MVBL, consists of four inexpensive compounds: L-selenium-methylselenocysteine (MSC), D-‍α‍-tocopheryl succinic acid (VES),β‍-carotene (β‍-Ca), and L-lysine (Lys).
MethodsThe effects of MVBL on cell viability, cell cycle, cell apoptosis, cell migration, cell invasion, reactive oxygen species (ROS), and paclitaxel (PTX)-combined treatment were studied in vitro. The inhibition of tumor metastasis, antioxidation, and immune enhancement capacity of MVBL were determined in vivo.
ResultsMVBL exhibited higher toxicity to tumor cells than to normal cells. It did not significantly affect the cell cycle of cancer cells, but increased their apoptosis. Wound healing, adhesion, and transwell assays showed that MVBL significantly inhibited tumor cell migration, adhesion, and invasion. MVBL sensitized MDA-MB-231 breast cancer cells to PTX, indicating that it can be used as an adjuvant to enhance the therapeutic effect of chemotherapy drugs. In mice, experimental data showed that MVBL inhibited tumor metastasis, prolonged their survival time, and enhanced their antioxidant capacity and immune function.
ConclusionsThis study revealed the roles of MVBL in improving immunity and antioxidation, preventing tumor growth, and inhibiting metastasis in vitro and in vivo. MVBL may be used as an adjuvant drug in cancer therapy for improving the survival and quality of life of cancer patients.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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