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On-line Access: 2023-04-10

Received: 2022-08-23

Revision Accepted: 2022-11-30

Crosschecked: 2023-04-14

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Shuangquan WU


Qifa YE


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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.4 P.345-351


A novel ameliorated rat model of reversible obstructive jaundice

Author(s):  Yongkang ZOU, Pengpeng YUE, Hankun CAO, Liqin WU, Li XU, Zhongzhong LIU, Shuangquan WU, Qifa YE

Affiliation(s):  Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, Wuhan 430071, China; more

Corresponding email(s):   yqf_china@163.com, shuangquanwu@whu.edu.cn

Key Words:  Animal model, Reversible obstructive jaundice, Bile duct ligation

Yongkang ZOU, Pengpeng YUE, Hankun CAO, Liqin WU, Li XU, Zhongzhong LIU, Shuangquan WU, Qifa YE. A novel ameliorated rat model of reversible obstructive jaundice[J]. Journal of Zhejiang University Science B, 2023, 24(4): 345-351.

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author="Yongkang ZOU, Pengpeng YUE, Hankun CAO, Liqin WU, Li XU, Zhongzhong LIU, Shuangquan WU, Qifa YE",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T A novel ameliorated rat model of reversible obstructive jaundice
%A Yongkang ZOU
%A Pengpeng YUE
%A Hankun CAO
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%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200421

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A1 - Yongkang ZOU
A1 - Pengpeng YUE
A1 - Hankun CAO
A1 - Liqin WU
A1 - Li XU
A1 - Zhongzhong LIU
A1 - Shuangquan WU
A1 - Qifa YE
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DOI - 10.1631/jzus.B2200421

Obstructive jaundice is a common clinical symptom generally caused by bile duct stones, inflammatory hyperplasia, and tumors. It is characterized by hyperbilirubinemia and may trigger a variety of complications such as hypotension, kidney injury, endotoxemia, multiple organ dysfunction syndrome, and even death (Pavlidis and Pavlidis, 2018; Liu et al., 2021). Relieving bile duct obstruction and providing adequate drainage have been considered as the most effective therapies for obstructive jaundice. However, it has not yet been established whether it is beneficial to treat affected patients by pre-operative biliary drainage (Blacker et al., 2021). Moreover, the pathophysiological changes or mechanisms associated with the reversal of organ function following the relief of bile-duct obstruction are unclear (Huang et al., 2004). Therefore, it is necessary to establish an experimental model of reversible obstructive jaundice to simulate biliary drainage in clinical practice.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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