CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2023-09-13
Cited: 0
Clicked: 1589
Citations: Bibtex RefMan EndNote GB/T7714
Xingguang ZHANG, Wei XU, Weilong ZHONG, Wencheng ZHANG, Cheng YANG, Lisa DUAN, Haiyan NIU, Yanmei DONG, Taotao LIU, Shihai XIA, Bangmao WANG. Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau[J]. Journal of Zhejiang University Science B, 2023, 24(9): 823-838.
@article{title="Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau",
author="Xingguang ZHANG, Wei XU, Weilong ZHONG, Wencheng ZHANG, Cheng YANG, Lisa DUAN, Haiyan NIU, Yanmei DONG, Taotao LIU, Shihai XIA, Bangmao WANG",
journal="Journal of Zhejiang University Science B",
volume="24",
number="9",
pages="823-838",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200509"
}
%0 Journal Article
%T Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau
%A Xingguang ZHANG
%A Wei XU
%A Weilong ZHONG
%A Wencheng ZHANG
%A Cheng YANG
%A Lisa DUAN
%A Haiyan NIU
%A Yanmei DONG
%A Taotao LIU
%A Shihai XIA
%A Bangmao WANG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 9
%P 823-838
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200509
TY - JOUR
T1 - Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau
A1 - Xingguang ZHANG
A1 - Wei XU
A1 - Weilong ZHONG
A1 - Wencheng ZHANG
A1 - Cheng YANG
A1 - Lisa DUAN
A1 - Haiyan NIU
A1 - Yanmei DONG
A1 - Taotao LIU
A1 - Shihai XIA
A1 - Bangmao WANG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 9
SP - 823
EP - 838
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200509
Abstract: The gut microbiome shows changes under a plateau environment, while the disbalance of intestinal microbiota plays an important role in the pathogenesis of irritable bowel syndrome (IBS); however, the relationship between the two remains unexplored. In this work, we followed up a healthy cohort for up to a year before and after living in a plateau environment and performed 16S ribosomal RNA (rRNA) sequencing analysis of their fecal samples. Through evaluating the participants’ clinical symptoms, combined with an IBS questionnaire, we screened the IBS sub-population in our cohort. The sequencing results showed that a high-altitude environment could lead to changes in the diversity and composition of gut flora. In addition, we found that the longer the time volunteers spent in the plateau environment, the more similar their gut microbiota composition and abundance became compared to those before entering the plateau, and IBS symptoms were significantly alleviated. Therefore, we speculated that the plateau may be a special environment that induces IBS. The taxonomic units g_Alistipes, g_Oscillospira, and s_Ruminococcus_torques, which had been proved to play important roles in IBS pathogenesis, were also abundant in the IBS cohort at high altitudes. Overall, the disbalance of gut microbiota induced by the plateau environment contributed to the high frequency of IBS and the psychosocial abnormalities associated with IBS. Our results prompt further research to elucidate the relevant mechanism.
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