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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2200344


Changes in the gut microbiota of osteoporosis patients based on 16s rRNA gene sequencing: a systematic review and meta-analysis


Author(s):  Rui HUANG, Pan LIU, Yiguang BAI, Jieqiong HUANG, Rui PAN, Huihua LI, Yeping SU, Quan ZHOU, Ruixin MA, Shaohui ZONG, Gaofeng ZENG

Affiliation(s):  College of Public Hygiene of Guangxi Medical University, Guangxi Medical University, Nanning, Guangxi, China; more

Corresponding email(s):   xiaohui3008@126.com, 1685858372@qq.com

Key Words:  Osteoporosis, Microbiome, Intestinal, 16S rRNA sequencing.


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Rui HUANG, Pan LIU, Yiguang BAI, Jieqiong HUANG, Rui PAN, Huihua LI, Yeping SU, Quan ZHOU, Ruixin MA, Shaohui ZONG, Gaofeng ZENG. Changes in the gut microbiota of osteoporosis patients based on 16s rRNA gene sequencing: a systematic review and meta-analysis[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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A1 - Yeping SU
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Abstract: 
(1) Background: osteoporosishas become a major public health issue, threatening the bone health of middle-aged and elderly people from all around the world. Changes in the gut microbiota are correlated with the maintenance of bone mass and bone quality. However, research results in this field remain highly controversial, and no systematic review or meta-analysis of the relationship between gut microbiota and osteoporosis has been conducted. This paper addresses this shortcoming, focusing on the difference in the gut microbiota abundance between osteoporosis patients and healthy controls based on previous 16S rRNA gene sequencing results, in order to provide new clinical reference information for future customized prevention and treatment options of osteoporosis; (2) Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), we comprehensively searched the databases of PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI). In addition, we applied the R programming language version 4.0.3 and Stata 15.1 software for data analysis. We also implemented the Newcastle-Ottawa Scale (NOS), funnel plot analysis, sensitivity analysis, Egger’s test, and Begg’s test to assess the risk of bias; (3)Results: This research ultimately considered 12 studies, which included the fecal gut microbiota data of 2,033 people [604 osteoporosis and 1,429 healthy controls]. In the included research papers, it was observed that the relative abundance of Lactobacillus and Ruminococcus increased in theosteoporosis group. while the relative abundance of Bacteroidetes and Bacteroides increased (except for Ireland). Meanwhile, Firmicutes, Blautia, Alistipes, Megamonas, and Anaerostipes showed a reduced relative abundance in the Chinese studies. In the Lefse analysis, certain bacteria showed statistically significant results consistently across different studies; (4) Conclusion: This observational meta-analysis revealed that changes in the gut microbiota were correlated with osteoporosis, and variations in some advantageous gut microbiota might involve regional differences.

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