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On-line Access: 2023-03-10

Received: 2022-12-07

Revision Accepted: 2023-01-06

Crosschecked: 2023-03-13

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 ORCID:

Xiaowei LUO

https://orcid.org/0000-0002-2114-1609

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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.3 P.275-280

http://doi.org/10.1631/jzus.B2200622


An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509


Author(s):  Miaoping LIN, Zhenzhou TANG, Jiaxi WANG, Humu LU, Chenwei WANG, Yanting ZHANG, Xinming LIU, Chenghai GAO, Yonghong LIU, Xiaowei LUO

Affiliation(s):  Institute of Marine Drugs, Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China

Corresponding email(s):   luoxiaowei1991@126.com

Key Words:  Emericella nidulans, Marine fungi, Aromatic polyketides, Epipolythiodioxopiperazines, Cytotoxicity


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Miaoping LIN, Zhenzhou TANG, Jiaxi WANG, Humu LU, Chenwei WANG, Yanting ZHANG, Xinming LIU, Chenghai GAO, Yonghong LIU, Xiaowei LUO. An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509[J]. Journal of Zhejiang University Science B, 2023, 24(3): 275-280.

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author="Miaoping LIN, Zhenzhou TANG, Jiaxi WANG, Humu LU, Chenwei WANG, Yanting ZHANG, Xinming LIU, Chenghai GAO, Yonghong LIU, Xiaowei LUO",
journal="Journal of Zhejiang University Science B",
volume="24",
number="3",
pages="275-280",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200622"
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%T An epipolythiodioxopiperazine alkaloid and diversified aromatic polyketides with cytotoxicity from the Beibu Gulf coral-derived fungus Emericella nidulans GXIMD 02509
%A Miaoping LIN
%A Zhenzhou TANG
%A Jiaxi WANG
%A Humu LU
%A Chenwei WANG
%A Yanting ZHANG
%A Xinming LIU
%A Chenghai GAO
%A Yonghong LIU
%A Xiaowei LUO
%J Journal of Zhejiang University SCIENCE B
%V 24
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A1 - Miaoping LIN
A1 - Zhenzhou TANG
A1 - Jiaxi WANG
A1 - Humu LU
A1 - Chenwei WANG
A1 - Yanting ZHANG
A1 - Xinming LIU
A1 - Chenghai GAO
A1 - Yonghong LIU
A1 - Xiaowei LUO
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Abstract: 
Marine microorganisms, especially marine fungi, have historically proven their value as a prolific source for structurally novel and pharmacologically active secondary metabolites (Deshmukh et al., 2018; Carroll et al., 2022). The corals constitute a dominant part of reefs with the highest biodiversity, and harbor highly diverse and abundant microbial symbionts in their tissue, skeleton, and mucus layer, with species-specific core members that are spatially partitioned across coral microhabitats (Wang WQ et al., 2022). The coral-associated fungi were very recently found to be vital producers of structurally diverse compounds, terpenes, alkaloids, peptides, aromatics, lactones, and steroids. They demonstrate a wide range of bioactivity such as anticancer, antimicrobial, and antifouling activity (Chen et al., 2022). The genetically powerful genus Emericella (Ascomycota), which has marine and terrestrial sources, includes over 30 species and is distributed worldwide. It is considered a rich source of diverse secondary metabolites with antimicrobial activity or cytotoxicity (Alburae et al., 2020). Notably, emericella nidulans, the sexual state of a classic biosynthetic strain Aspergillus nidulans, was recently reported as an important source of highly methylated polyketides (Li et al., 2019) and isoindolone-containing meroterpenoids (Zhou et al., 2016) with unusual skeletons.

北部湾珊瑚来源构巢裸胞壳菌GXIMD 02509中具有细胞毒性的一个多硫代二酮哌嗪生物碱和结构多样的芳香聚酮类化合物

林妙萍,唐振洲,王佳熹,卢护木,王晨蔚,张艳婷,刘昕明,高程海,刘永宏,罗小卫
广西中医药大学,海洋药物研究院/广西海洋药物重点实验室,中国南宁市,530200
概要:北部湾藴育着丰富且亟待研究的海洋(微)生物资源,是活性天然产物的重要来源。本研究从涠洲岛珊瑚共附生构巢裸胞壳菌GXIMD 02509中分离获得一个多硫代二酮哌嗪生物碱和系列芳香聚酮类化合物,包含一个新化合物4a-O-methoxyarugosin H (1)。我们通过采用多种波、光谱学技术及对比文献方法鉴定了化合物的化学结构。化合物1~5710对786-O、SW1990和SW480等3株肿瘤细胞增殖具抑制活性,半抑制浓度(IC50)值为4.3~33.4 μmol/L。化合物emestrin J (10)具有一个二硫桥键,还能够显著抑制786-O细胞克隆及迁移,诱导786-O细胞凋亡并阻滞细胞分裂在G2/M期,是一个潜在具抗肿瘤活性的先导化合物。

关键词:巢裸胞壳菌;海洋真菌;芳香聚酮;多硫代二酮哌嗪;细胞毒

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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