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On-line Access: 2023-11-14

Received: 2023-01-09

Revision Accepted: 2023-05-21

Crosschecked: 2023-11-15

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xi-Ping Zhang

https://orcid.org/0000-0002-3556-9681

Hongjian YANG

https://orcid.org/0000-0003-1583-2814

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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.11 P.985-997

http://doi.org/10.1631/jzus.B2300019


Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer


Author(s):  Qiuhui YANG, Yeqin FU, Jiaxuan WANG, Hongjian YANG, Xiping ZHANG

Affiliation(s):  Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China; more

Corresponding email(s):   yhjzlyy@163.com, zxp99688@sina.com

Key Words:  Breast cancer, Sentinel lymph node (SLN), Contrast-enhanced ultrasound (CEUS), Ultrasound contrast agent (UCA)


Qiuhui YANG, Yeqin FU, Jiaxuan WANG, Hongjian YANG, Xiping ZHANG. Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer[J]. Journal of Zhejiang University Science B, 2023, 24(11): 985-997.

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journal="Journal of Zhejiang University Science B",
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year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300019"
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%A Qiuhui YANG
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%A Jiaxuan WANG
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%A Xiping ZHANG
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T1 - Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer
A1 - Qiuhui YANG
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A1 - Hongjian YANG
A1 - Xiping ZHANG
J0 - Journal of Zhejiang University Science B
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DOI - 10.1631/jzus.B2300019


Abstract: 
Sentinel lymph nodes (SLNs) are the first station of lymph nodes that extend from the breast tumor to the axillary lymphatic drainage. The pathological status of these LNs can predict that of the entire axillary lymph node. Therefore, the accurate identification of SLNs is necessary for sentinel lymph node biopsy (SLNB) to replace axillary lymph node dissection (ALND). The quality of life and prognosis of breast cancer patients are related to proper surgical treatment after the precise identification of SLNs. Some of the SLN tracers that have been identified include radioisotope, nano-carbon, indocyanine green (ICG), and methylene blue (MB). However, these tracers have certain limitations, such as pigmentation, radiation dangers, and the requirement for costly detection equipment. Ultrasound contrast agents (UCAs) have good specificity and sensitivity, and thus can compensate for some shortcomings of the mentioned tracers. This technique is also being applied to SLNB in patients with breast cancer, and can even provide an initial judgment on SLN status. contrast-enhanced ultrasound (CEUS) has the advantages of high distinguishability, simple operation, no radiation harm, low cost, and accurate localization; therefore, it is expected to replace the traditional biopsy methods. In addition, it can significantly enhance the accuracy of SLN localization and shorten the operation time.

超声造影在乳腺癌前哨淋巴结定位和诊断中的优势

杨秋辉1,2, 傅烨钦1,2,王嘉萱3,杨红健1,张喜平1
1浙江省肿瘤医院乳腺外科,中国科学院杭州医学研究所,中国杭州市,310022
2温州医科大学研究生培养基地(浙江省肿瘤医院),中国杭州市,310022
3山西医科大学第一临床医学院,中国晋中市,030600
摘要:前哨淋巴结(SLN)是指从乳腺原发肿瘤到腋窝淋巴引流途径中的第一站淋巴结,这些淋巴结的病理状态可以预测整个腋窝淋巴结的情况。因此,准确识别SLN是前哨淋巴结活检(SLNB)替代腋窝淋巴结清扫(ALND)的关键。乳腺癌患者的生活质量和预后与识别SLN后的手术方式有关。目前常用的一些SLN示踪剂包括放射性同位素、纳米碳、吲哚菁绿(ICG)和亚甲蓝(MB)。然而,这些示踪剂都有一定的局限性,如色素沉着、放射性损害以及所需设备价格昂贵。超声造影剂所具有的简便性和安全性可以弥补上述示踪剂的一些不足。该技术也被应用到乳腺癌患者的SLNB,甚至可以初步判断SLN的状态。由于超声造影技术(CEUS)具有高识别率、易操作、无辐射、低成本、定位准确等优点,有望取代传统的活检方法。此外,它还可以显著提高SLN定位的准确性,并有效缩短手术时间。

关键词:乳腺癌;前哨淋巴结(SLN);超声造影(CEUS);超声造影剂(UCA)

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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