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On-line Access: 2023-11-14

Received: 2023-01-09

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Xi-Ping Zhang


Hongjian YANG


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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.11 P.985-997


Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer

Author(s):  Qiuhui YANG, Yeqin FU, Jiaxuan WANG, Hongjian YANG, Xiping ZHANG

Affiliation(s):  Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China; more

Corresponding email(s):   yhjzlyy@163.com, zxp99688@sina.com

Key Words:  Breast cancer, Sentinel lymph node (SLN), Contrast-enhanced ultrasound (CEUS), Ultrasound contrast agent (UCA)

Qiuhui YANG, Yeqin FU, Jiaxuan WANG, Hongjian YANG, Xiping ZHANG. Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer[J]. Journal of Zhejiang University Science B, 2023, 24(11): 985-997.

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author="Qiuhui YANG, Yeqin FU, Jiaxuan WANG, Hongjian YANG, Xiping ZHANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer
%A Qiuhui YANG
%A Yeqin FU
%A Jiaxuan WANG
%A Hongjian YANG
%A Xiping ZHANG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 11
%P 985-997
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300019

T1 - Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer
A1 - Qiuhui YANG
A1 - Yeqin FU
A1 - Jiaxuan WANG
A1 - Hongjian YANG
A1 - Xiping ZHANG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 11
SP - 985
EP - 997
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300019

Sentinel lymph nodes (SLNs) are the first station of lymph nodes that extend from the breast tumor to the axillary lymphatic drainage. The pathological status of these LNs can predict that of the entire axillary lymph node. Therefore, the accurate identification of SLNs is necessary for sentinel lymph node biopsy (SLNB) to replace axillary lymph node dissection (ALND). The quality of life and prognosis of breast cancer patients are related to proper surgical treatment after the precise identification of SLNs. Some of the SLN tracers that have been identified include radioisotope, nano-carbon, indocyanine green (ICG), and methylene blue (MB). However, these tracers have certain limitations, such as pigmentation, radiation dangers, and the requirement for costly detection equipment. Ultrasound contrast agents (UCAs) have good specificity and sensitivity, and thus can compensate for some shortcomings of the mentioned tracers. This technique is also being applied to SLNB in patients with breast cancer, and can even provide an initial judgment on SLN status. contrast-enhanced ultrasound (CEUS) has the advantages of high distinguishability, simple operation, no radiation harm, low cost, and accurate localization; therefore, it is expected to replace the traditional biopsy methods. In addition, it can significantly enhance the accuracy of SLN localization and shorten the operation time.


杨秋辉1,2, 傅烨钦1,2,王嘉萱3,杨红健1,张喜平1


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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