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Sebastian LEPTIHN


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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.3 P.181-196


Defense and anti-defense mechanisms of bacteria and bacteriophages

Author(s):  Xiaoqing WANG, Sebastian LEPTIHN

Affiliation(s):  School of Medicine, Lishui University, Lishui 323000, China; more

Corresponding email(s):   11818142@zju.edu.cn

Key Words:  Bacteriophage, Phage resistance, Abortive infection, Phage therapy

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Xiaoqing WANG, Sebastian LEPTIHN. Defense and anti-defense mechanisms of bacteria and bacteriophages[J]. Journal of Zhejiang University Science B, 2024, 25(3): 181-196.

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author="Xiaoqing WANG, Sebastian LEPTIHN",
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%T Defense and anti-defense mechanisms of bacteria and bacteriophages
%A Xiaoqing WANG
%A Sebastian LEPTIHN
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%DOI 10.1631/jzus.B2300101

T1 - Defense and anti-defense mechanisms of bacteria and bacteriophages
A1 - Xiaoqing WANG
A1 - Sebastian LEPTIHN
J0 - Journal of Zhejiang University Science B
VL - 25
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EP - 196
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Y1 - 2024
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2300101

In the post-antibiotic era, the overuse of antimicrobials has led to a massive increase in antimicrobial resistance, leaving medical doctors few or no treatment options to fight infections caused by superbugs. The use of bacteriophages is a promising alternative to treat infections, supplementing or possibly even replacing antibiotics. Using phages for therapy is possible, since these bacterial viruses can kill bacteria specifically, causing no harm to the normal flora. However, bacteria have developed a multitude of sophisticated and complex ways to resist infection by phages, including abortive infection and the clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system. Phages also can evolve and acquire new anti-defense strategies to continue predation. An in-depth exploration of both defense and anti-defense mechanisms would contribute to optimizing phage therapy, while we would also gain novel insights into the microbial world. In this paper, we summarize recent research on bacterial phage resistance and phage anti-defense mechanisms, as well as collaborative win-win systems involving both virus and host.


汪晓庆1,Sebastian LEPTIHN2,3
2爱丁堡大学医学院,医学与兽医学院,英国爱丁堡,EH8 9JZ


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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