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CLC number: R378

On-line Access: 2016-03-07

Received: 2015-03-19

Revision Accepted: 2015-11-30

Crosschecked: 2016-02-15

Cited: 4

Clicked: 3262

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Ming-xi Wang

http://orcid.org/0000-0002-8093-0384

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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.3 P.188-199

http://doi.org/10.1631/jzus.B1500068


Antibiotic resistance mechanisms of Myroides sp.


Author(s):  Shao-hua Hu, Shu-xing Yuan, Hai Qu, Tao Jiang, Ya-jun Zhou, Ming-xi Wang, De-song Ming

Affiliation(s):  Yun Leung Laboratory for Molecular Diagnostics, School of Biomedical Sciences and Institute of Molecular Medicine, Huaqiao University / Engineering Research Center of Molecular Medicine, Ministry of Education, Xiamen 361021, China; more

Corresponding email(s):   mxwang@hqu.edu.cn, mds6430@126.com

Key Words:  Myroides sp., Antibiotic resistance, Identification methods, 16S ribosomal RNA gene sequencing, Next generation sequencing


Shao-hua Hu, Shu-xing Yuan, Hai Qu, Tao Jiang, Ya-jun Zhou, Ming-xi Wang, De-song Ming. Antibiotic resistance mechanisms of Myroides sp.[J]. Journal of Zhejiang University Science B, 2016, 17(3): 188-199.

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author="Shao-hua Hu, Shu-xing Yuan, Hai Qu, Tao Jiang, Ya-jun Zhou, Ming-xi Wang, De-song Ming",
journal="Journal of Zhejiang University Science B",
volume="17",
number="3",
pages="188-199",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500068"
}

%0 Journal Article
%T Antibiotic resistance mechanisms of Myroides sp.
%A Shao-hua Hu
%A Shu-xing Yuan
%A Hai Qu
%A Tao Jiang
%A Ya-jun Zhou
%A Ming-xi Wang
%A De-song Ming
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 3
%P 188-199
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500068

TY - JOUR
T1 - Antibiotic resistance mechanisms of Myroides sp.
A1 - Shao-hua Hu
A1 - Shu-xing Yuan
A1 - Hai Qu
A1 - Tao Jiang
A1 - Ya-jun Zhou
A1 - Ming-xi Wang
A1 - De-song Ming
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 3
SP - 188
EP - 199
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500068


Abstract: 
Bacteria of the genus Myroides (Myroides spp.) are rare opportunistic pathogens. Myroides sp. infections have been reported mainly in China. Myroides sp. is highly resistant to most available antibiotics, but the resistance mechanisms are not fully elucidated. Current strain identification methods based on biochemical traits are unable to identify strains accurately at the species level. While 16S ribosomal RNA (rRNA) gene sequencing can accurately achieve this, it fails to give information on the status and mechanisms of antibiotic resistance, because the 16S rRNA sequence contains no information on resistance genes, resistance islands or enzymes. We hypothesized that obtaining the whole genome sequence of Myroides sp., using next generation sequencing methods, would help to clarify the mechanisms of pathogenesis and antibiotic resistance, and guide antibiotic selection to treat Myroides sp. infections. As Myroides sp. can survive in hospitals and the environment, there is a risk of nosocomial infections and pandemics. For better management of Myroides sp. infections, it is imperative to apply next generation sequencing technologies to clarify the antibiotic resistance mechanisms in these bacteria.

芳香黄杆菌的耐药机制

概要:芳香黄杆菌广泛耐药,一旦感染很难治愈。其耐药机制尚不清楚,需要进一步研究。本文对国内外的芳香黄杆菌病例进行全面总结,分析该细菌的抗生素耐药情况、耐药机制、病人预后、医院内爆发感染和流行的风险,以及目前实验室应用的诊断方法,指出全基因组测序应用于阐明其耐药机制的可行性和迫切性。
关键词:芳香黄杆菌;抗生素耐药;鉴定方法;16S rRNA 基因测序;下一代测序

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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