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CLC number: TP212.3; Q189

On-line Access: 2014-10-09

Received: 2014-04-26

Revision Accepted: 2014-07-13

Crosschecked: 2014-09-17

Cited: 1

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE C 2014 Vol.15 No.10 P.813-820


Exploring the mechanism of neural-function reconstruction by reinnervated nerves in targeted muscles

Author(s):  Hui Zhou, Lin Yang, Feng-xia Wu, Jian-ping Huang, Liang-qing Zhang, Ying-jian Yang, Guang-lin Li

Affiliation(s):  Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; more

Corresponding email(s):   gl.li@siat.ac.cn

Key Words:  Neural function reconstruction, Targeted muscle reinnervation, Intramuscular myoelectric signal, Myoelectric prostheses

Hui Zhou, Lin Yang, Feng-xia Wu, Jian-ping Huang, Liang-qing Zhang, Ying-jian Yang, Guang-lin Li. Exploring the mechanism of neural-function reconstruction by reinnervated nerves in targeted muscles[J]. Journal of Zhejiang University Science C, 2014, 15(10): 813-820.

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author="Hui Zhou, Lin Yang, Feng-xia Wu, Jian-ping Huang, Liang-qing Zhang, Ying-jian Yang, Guang-lin Li",
journal="Journal of Zhejiang University Science C",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Exploring the mechanism of neural-function reconstruction by reinnervated nerves in targeted muscles
%A Hui Zhou
%A Lin Yang
%A Feng-xia Wu
%A Jian-ping Huang
%A Liang-qing Zhang
%A Ying-jian Yang
%A Guang-lin Li
%J Journal of Zhejiang University SCIENCE C
%V 15
%N 10
%P 813-820
%@ 1869-1951
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.C1400154

T1 - Exploring the mechanism of neural-function reconstruction by reinnervated nerves in targeted muscles
A1 - Hui Zhou
A1 - Lin Yang
A1 - Feng-xia Wu
A1 - Jian-ping Huang
A1 - Liang-qing Zhang
A1 - Ying-jian Yang
A1 - Guang-lin Li
J0 - Journal of Zhejiang University Science C
VL - 15
IS - 10
SP - 813
EP - 820
%@ 1869-1951
Y1 - 2014
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.C1400154

A lack of myoelectric sources after limb amputation is a critical challenge in the control of multifunctional motorized prostheses. To reconstruct myoelectric sources physiologically related to lost limbs, a newly proposed neural-function construction method, targeted muscle reinnervation (TMR), appears promising. Recent advances in the TMR technique suggest that TMR could provide additional motor command information for the control of multifunctional myoelectric prostheses. However, little is known about the nature of the physiological functional recovery of the reinnervated muscles. More understanding of the underlying mechanism of TMR could help us fine tune the technique to maximize its capability to achieve a much higher performance in the control of multifunctional prostheses. In this study, rats were used as an animal model for TMR surgery involving transferring a median nerve into the pectoralis major, which served as the target muscle. intramuscular myoelectric signals reconstructed following TMR were recorded by implanted wire electrodes and analyzed to explore the nature of the neural-function reconstruction achieved by reinnervation of targeted muscles. Our results showed that the active myoelectric signal reconstructed in the targeted muscle was acquired one week after TMR surgery, and its amplitude gradually became stronger over time. These preliminary results from rats may serve as a basis for exploring the mechanism of neural-function reconstruction by the TMR technique in human subjects.


研究目的:靶向肌肉神经重建(target muscle reinnervation, TMR)技术通过对靶向肌肉植入新的神经,实现神经对靶向肌肉的重新支配。TMR技术可以为截肢患者提供丰富的肌电信息源,并可实现对假肢的直觉控制。临床上TMR已取得成功,但神经重建后功能康复过程和机理的研究仍然缺乏。本文通过建立基于大鼠的靶向肌肉神经重建模型,研究神经重建后神经肌肉功能的重建过程与潜在机理。

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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