JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis

Author(s): Shu Sian HOW, Sylvia CHIENG, Sheila NATHAN, Su Datt LAM
Affiliation(s): Department of Biological Sciences & more
Corresponding email(s): sylvia@ukm.edu.my
Key Words: ABC transporters; Bacterial pathogenesis; Virulence

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Shu Sian HOW, Sylvia CHIENG, Sheila NATHAN, Su Datt LAM. ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300641

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%T ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis
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%A Sylvia CHIENG
%A Sheila NATHAN
%A Su Datt LAM
%J Journal of Zhejiang University SCIENCE B
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doi="https://doi.org/10.1631/jzus.B2300641"

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A1 - Sheila NATHAN
A1 - Su Datt LAM
J0 - Journal of Zhejiang University Science B
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Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300641"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: ATP-binding cassette (ABC) transporter systems are divided into importers and exporters that facilitate the movement of diverse substrate molecules across the lipid bilayer, against the concentration gradient. These transporters comprise two highly conserved nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs). Unlike ABC exporters, prokaryotic ABC importers require an additional substrate-binding protein (SBP) as a recognition site for specific substrate translocation. The discovery of a large number of ABC systems in bacterial pathogens revealed that these transporters are crucial for the establishment of bacterial infections. The existing literature has highlighted the roles of ABC transporters in bacterial growth, pathogenesis, and virulence. These roles include importing essential nutrients required for a variety of cellular processes and exporting outer membrane-associated virulence factors and antimicrobial substances. This review outlines the general structures and classification of ABC systems to provide a comprehensive view of the activities and roles of ABC transporters associated with bacterial virulence and pathogenesis during infection.

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