CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 0
Clicked: 751
Shu Sian HOW, Sylvia CHIENG, Sheila NATHAN, Su Datt LAM. ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis",
author="Shu Sian HOW, Sylvia CHIENG, Sheila NATHAN, Su Datt LAM",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300641"
}
%0 Journal Article
%T ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis
%A Shu Sian HOW
%A Sylvia CHIENG
%A Sheila NATHAN
%A Su Datt LAM
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300641
TY - JOUR
T1 - ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis
A1 - Shu Sian HOW
A1 - Sylvia CHIENG
A1 - Sheila NATHAN
A1 - Su Datt LAM
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300641
Abstract: ATP-binding cassette (ABC) transporter systems are divided into importers and exporters that facilitate the movement of diverse substrate molecules across the lipid bilayer, against the concentration gradient. These transporters comprise two highly conserved nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs). Unlike ABC exporters, prokaryotic ABC importers require an additional substrate-binding protein (SBP) as a recognition site for specific substrate translocation. The discovery of a large number of ABC systems in bacterial pathogens revealed that these transporters are crucial for the establishment of bacterial infections. The existing literature has highlighted the roles of ABC transporters in bacterial growth, pathogenesis, and virulence. These roles include importing essential nutrients required for a variety of cellular processes and exporting outer membrane-associated virulence factors and antimicrobial substances. This review outlines the general structures and classification of ABC systems to provide a comprehensive view of the activities and roles of ABC transporters associated with bacterial virulence and pathogenesis during infection.
Open peer comments: Debate/Discuss/Question/Opinion
<1>