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Bio-Design and Manufacturing  2018 Vol.1 No.4 P.254-264

http://doi.org/10.1007/s42242-018-0027-9


Origami meets electrospinning: a new strategy for 3D nanofiber scaffolds


Author(s):  Juqing Song, Guanglin Zhu, Huichang Gao, Lin Wang, Nanying Li, Xuetao Shi, Yingjun Wang

Affiliation(s):  National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, Peoples Republic of China; more

Corresponding email(s):   shxt@scut.edu.cn, imwangyj@163.com

Key Words:  Electrospinning, Origami, 3D construction, Nano?ber scaffold/cells complex


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Juqing Song, Guanglin Zhu, Huichang Gao, Lin Wang, Nanying Li, Xuetao Shi, Yingjun Wang. Origami meets electrospinning: a new strategy for 3D nanofiber scaffolds[J]. Journal of Zhejiang University Science D, 2018, 1(4): 254-264.

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author="Juqing Song, Guanglin Zhu, Huichang Gao, Lin Wang, Nanying Li, Xuetao Shi, Yingjun Wang",
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doi="10.1007/s42242-018-0027-9"
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Abstract: 
Inspired by the constitution of things in the natural world, three-dimensional (3D) nano?ber scaffold/cells complex was constructed via the combination of electrospinning technology and origami techniques. The nano?ber boxes prepared by origami provided a limited space for the layer-by-layer nano?ber ?lms, and the human fetal osteoblasts (hFOBs) seeded on the both sides of the nano?ber ?lms were expected to facilitate the bonding of the adjacent nano?ber ?lms through the secretion of extracellular matrix. Speci?cally, the hFOBs presented 3D distribution in the nano?ber scaffold, and they can stretch across the gaps between the adjacent nano?ber ?lms, forming the cell layers and ?lling the whole 3D nano?ber scaffold.Eventually,a3Dblockcomposedofelectrospunnano?berscaffoldandcellswasobtained,whichpossessespotential applications in bone tissue engineering. Interestingly, we also created 3D nano?ber structures that range from simple forms to intricate architectures via origami, indicating that the combination of electrospinning technology and origami techniques is a feasible method for the 3D construction of tissue engineering scaffolds.

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