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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Injectable bioactive polymethyl methacrylate–hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty
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Xin Sun, Xin Zhang, Xin Jiao, Jie Ma, Xingzhen Liu, Han Yang, Kangping Shen, Yaokai Gan, Jinwu Wang, Haiyan Li & Wenjie Jin. Injectable bioactive polymethyl methacrylate–hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty[J]. Journal of Zhejiang University Science D, 2022, 5(2): 318-332.
@article{title="Injectable bioactive polymethyl methacrylate–hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty",
author="Xin Sun, Xin Zhang, Xin Jiao, Jie Ma, Xingzhen Liu, Han Yang, Kangping Shen, Yaokai Gan, Jinwu Wang, Haiyan Li & Wenjie Jin",
journal="Journal of Zhejiang University Science D",
volume="5",
number="2",
pages="318-332",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00172-1"
}
%0 Journal Article
%T Injectable bioactive polymethyl methacrylate–hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty
%A Xin Sun
%A Xin Zhang
%A Xin Jiao
%A Jie Ma
%A Xingzhen Liu
%A Han Yang
%A Kangping Shen
%A Yaokai Gan
%A Jinwu Wang
%A Haiyan Li & Wenjie Jin
%J Journal of Zhejiang University SCIENCE D
%V 5
%N 2
%P 318-332
%@ 1869-1951
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00172-1
TY - JOUR
T1 - Injectable bioactive polymethyl methacrylate–hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty
A1 - Xin Sun
A1 - Xin Zhang
A1 - Xin Jiao
A1 - Jie Ma
A1 - Xingzhen Liu
A1 - Han Yang
A1 - Kangping Shen
A1 - Yaokai Gan
A1 - Jinwu Wang
A1 - Haiyan Li & Wenjie Jin
J0 - Journal of Zhejiang University Science D
VL - 5
IS - 2
SP - 318
EP - 332
%@ 1869-1951
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00172-1
Abstract: Polymethyl methacrylate (PMMA) bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP). However, applications of PMMA bone cement are limited by the high elasticity modulus of PMMA, its low biodegradability, and its limited ability to regenerate bone. To improve PMMA bioactivity and biodegradability and to modify its elasticity modulus, we mixed PMMA bone cement with oxidized hyaluronic acid and carboxymethyl chitosan in situ cross-linking hydrogel loaded with bone morphogenetic protein-2 (BMP-2) to achieve novel hybrid cement. These fabricated PMMA–hydrogel hybrid cements exhibited lower setting temperatures, a lower elasticity modulus, and better biodegradability and biocompatibility than that of pure PMMA cement, while retaining acceptable setting times, mechanical strength, and injectability. In addition, we detected release of BMP-2 from the PMMA–hydrogel hybrid cements, significantly enhancing in vitro osteogenesis of bone marrow mesenchymal stem cells by up-regulating the gene expression of Runx2, Col1, and OPN. Use of PMMA–hydrogel hybrid cements loaded with BMP-2 on rabbit femoral condyle bone-defect models revealed their biodegradability and enhanced bone formation. Our study demonstrated the favorable mechanical properties, biocompatibility, and biodegradability of fabricated PMMA–hydrogel hybrid cements loaded with BMP-2, as well as their ability to improve osteogenesis, making them a promising material for use in PKP and PVP.
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