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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Light/pH dual controlled drug release “nanocontainer” alleviates tumor hypoxia for synergistic enhanced chemotherapy, photodynamic therapy and chemodynamic therapy
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Shihe Liu, Xin Zhang, Zhimin Bai, Yibo Yang, Jia Zhang, Kun Li, Zhiwei Liu, Ming Shi, Lixin Dong, Jidong Wang, Jian Li. Light/pH dual controlled drug release “nanocontainer” alleviates tumor hypoxia for synergistic enhanced chemotherapy, photodynamic therapy and chemodynamic therapy[J]. Journal of Zhejiang University Science , , (): .
@article{title="Light/pH dual controlled drug release “nanocontainer”
alleviates tumor hypoxia for synergistic enhanced
chemotherapy, photodynamic therapy and chemodynamic
therapy",
author="Shihe Liu, Xin Zhang, Zhimin Bai, Yibo Yang, Jia Zhang, Kun Li, Zhiwei Liu, Ming Shi, Lixin Dong, Jidong Wang, Jian Li",
journal="Journal of Zhejiang University Science ",
volume="",
number="",
pages="",
year="",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00310-5"
}
%0 Journal Article
%T Light/pH dual controlled drug release “nanocontainer”
alleviates tumor hypoxia for synergistic enhanced
chemotherapy, photodynamic therapy and chemodynamic
therapy
%A Shihe Liu
%A Xin Zhang
%A Zhimin Bai
%A Yibo Yang
%A Jia Zhang
%A Kun Li
%A Zhiwei Liu
%A Ming Shi
%A Lixin Dong
%A Jidong Wang
%A Jian Li
%J Journal of Zhejiang University SCIENCE
%V
%N
%P
%@ 1869-1951
%D
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00310-5
TY - JOUR
T1 - Light/pH dual controlled drug release “nanocontainer”
alleviates tumor hypoxia for synergistic enhanced
chemotherapy, photodynamic therapy and chemodynamic
therapy
A1 - Shihe Liu
A1 - Xin Zhang
A1 - Zhimin Bai
A1 - Yibo Yang
A1 - Jia Zhang
A1 - Kun Li
A1 - Zhiwei Liu
A1 - Ming Shi
A1 - Lixin Dong
A1 - Jidong Wang
A1 - Jian Li
J0 - Journal of Zhejiang University Science
VL -
IS -
SP -
EP -
%@ 1869-1951
Y1 -
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-024-00310-5
Abstract: photodynamic therapy (PDT) has significant advantages in treating primary tumors. However, the hypoxic tumor
microenvironment hinders the generation of sufficient reactive oxygen species during PDT to effectively kill
tumor cells, further greatly limiting the applications of PDT in cancer treatment. Herein, we reported a
temperature/pH dual controlled drug delivery system LPC@PCN@PDA/Fe3+-AS1411 based on a porous
coordination network (Mn) coated with polydopamine (PDA) and modified with an aptamer AS1411. β-lapachone
(LPC) was loaded inside the porous coordination network (Mn) framework, and Fe3+ was attached to the surface
of the PDA coating. These nanoparticles (NPs) exhibited excellent multimodal cancer therapeutic effects and
tumor targeting ability with their photo- and chemodynamic properties. The therapeutic effect can be enhanced
by the production of sufficient oxygen by the internal hydrogen peroxide, which improves the photodynamic
effect of the photosensitizer porous coordination network (Mn) and the chemotherapy effect of β-lapachone.
Notably, the conversion of Fe2+ to Fe3+ in the tumor cells exerts the fenton effect, which generates hydroxyl
radicals that cause lipid peroxidation in tumor cells and induce apoptosis, thus enhancing the chemodynamic
therapeutic effect. In vitro and in vivo experiments revealed that the NPs demonstrated specific tumor targeting,
excellent inhibition effect on tumor growth, and biocompatibility. Together, our findings can help develop an
intelligent multifunctional therapeutic nanoplatform for cancer therapy.
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