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Face/on: the future of craniofacial medicine through cell-based biofabrication
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Anna Kardosh, Anastasiia Sivodedova, Polina Bikmulina, Yuliya Nashchekina, Zeynep Burcin Gonen, Igor Ashurko, Anastasia Shpichka, Svetlana Tarasenko, Vladimir Yudin, Peter Timashev. Face/on: the future of craniofacial medicine through cell-based biofabrication[J]. Journal of Zhejiang University Science D, 2026, 9(5): 880 - 913.
@article{title="Face/on: the future of craniofacial medicine through cell-based biofabrication",
author="Anna Kardosh, Anastasiia Sivodedova, Polina Bikmulina, Yuliya Nashchekina, Zeynep Burcin Gonen, Igor Ashurko, Anastasia Shpichka, Svetlana Tarasenko, Vladimir Yudin, Peter Timashev",
journal="Journal of Zhejiang University Science D",
volume="9",
number="5",
pages="880 - 913",
year="2026",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500490"
}
%0 Journal Article
%T Face/on: the future of craniofacial medicine through cell-based biofabrication
%A Anna Kardosh
%A Anastasiia Sivodedova
%A Polina Bikmulina
%A Yuliya Nashchekina
%A Zeynep Burcin Gonen
%A Igor Ashurko
%A Anastasia Shpichka
%A Svetlana Tarasenko
%A Vladimir Yudin
%A Peter Timashev
%J Journal of Zhejiang University SCIENCE D
%V 9
%N 5
%P 880 - 913
%@ 1869-1951
%D 2026
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500490
TY - JOUR
T1 - Face/on: the future of craniofacial medicine through cell-based biofabrication
A1 - Anna Kardosh
A1 - Anastasiia Sivodedova
A1 - Polina Bikmulina
A1 - Yuliya Nashchekina
A1 - Zeynep Burcin Gonen
A1 - Igor Ashurko
A1 - Anastasia Shpichka
A1 - Svetlana Tarasenko
A1 - Vladimir Yudin
A1 - Peter Timashev
J0 - Journal of Zhejiang University Science D
VL - 9
IS - 5
SP - 880
EP - 913
%@ 1869-1951
Y1 - 2026
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500490
Abstract: Traumatic injuries to the craniofacial skeleton, along with diseases and structural defects affecting oral tissues—including teeth, gums, and the periodontal complex—are among the most prevalent pathological conditions in humans. Over the course of a lifetime, nearly everyone requires some form of dental or maxillofacial care. While current routine clinical procedures—such as surgical reconstructions, tissue grafting, and prosthetic restoration—provide varying degrees of therapeutic benefit, they often fail to fully restore the complex architecture and functions of craniofacial tissues. This limitation primarily reflects the intricate organization of the maxillofacial region, in which soft and hard tissues are tightly coordinated within a precisely regulated anatomical framework. Emerging cell-based biofabrication technologies, such as organoids, three-dimensional bioprinting, and microfluidic organ-on-chip systems, offer promising strategies for improving tissue equivalents and in vitro tissue models, bringing their architecture and functional properties closer to native tissues. In this review, we examine recent advances in craniofacial cell-based biofabrication, focusing on the development of oral tissue organoids, advanced bioprinting techniques—including in situ bioprinting, four-dimensional bioprinting, and volumetric bioprinting—and the implementation of craniofacial organ-on-chip systems. Furthermore, we discuss the principal challenges currently limiting the field and outline prospective directions that may guide the next generation of cranial and oral tissue engineering.
Full Text:
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CLC number:
On-line Access: 2026-07-01
Received: 2025-09-24
Revision Accepted: 2026-01-23
Crosschecked: 0000-00-00
Cited:
Clicked: 58
Open peer comments: Debate/Discuss/Question/Opinion
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