Full Text:
<3799>
CLC number: TQ466.5
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 1
Clicked: 7094
Preparation of natural α-tocopherol from non-α-tocopherols
| |||||||||||||
YANG Yi-wen, WEN Guang-dong, WU Cai-juan, REN Qi-long, WU Ping-dong. Preparation of natural α-tocopherol from non-α-tocopherols[J]. Journal of Zhejiang University Science A, 2004, 5(12): 1524-1527.
@article{title="Preparation of natural α-tocopherol from non-α-tocopherols",
author="YANG Yi-wen, WEN Guang-dong, WU Cai-juan, REN Qi-long, WU Ping-dong",
journal="Journal of Zhejiang University Science A",
volume="5",
number="12",
pages="1524-1527",
year="2004",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.1524"
}
%0 Journal Article
%T Preparation of natural α-tocopherol from non-α-tocopherols
%A YANG Yi-wen
%A WEN Guang-dong
%A WU Cai-juan
%A REN Qi-long
%A WU Ping-dong
%J Journal of Zhejiang University SCIENCE A
%V 5
%N 12
%P 1524-1527
%@ 1869-1951
%D 2004
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.1524
TY - JOUR
T1 - Preparation of natural α-tocopherol from non-α-tocopherols
A1 - YANG Yi-wen
A1 - WEN Guang-dong
A1 - WU Cai-juan
A1 - REN Qi-long
A1 - WU Ping-dong
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 12
SP - 1524
EP - 1527
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2004.1524
Abstract: Non-α-tocopherols are hydroxymethylated and hydrogenated to produce α-tocopherol in one pot process by simultaneously reacting with paraformaldehyde and hydrogen in the presence of catalysts of benzenesulfonic acid and 5% Pd/C in an autoclave. Effects of various operation conditions have been studied. The preferable reaction conditions are: temperature 180 °C to 200 °C, pressure 5.0 MPa, acid concentration 0.5 g/100 ml ethanol, mass ratio of Pd/C to tocopherols 7.1 g/100 g, and reaction time 5.0 h. A product with α-tocopherol content of 80% was obtained by using a raw material with a total tocopherols content of 80.54%. The conversion of non-α-tocopherols is almost 100%, and the mole yield of α-tocopherol is more than 90%.
[1] Baldwin, W.S., Willging, S.M., Siegel, B.M., 1990. Production of D-alpha-Tocopherol from Natural Plant Sources. US 4,977,282.
[2] Breuninger, M., 1999. Process for Permethylating non-α-Tocopherols to Produce α-Tocopherol. US 5,932,748.
[3] Brüggemann, K., Herguijuela, J.R., Netscher, T., Riegl, J., 1999. Hydroxymethylation of Tocopherols. US 5,892,058.
[4] Dutta-Roy, A.K., 1999. Molecular mechanism of cellular uptake and intracellular translocation of α-tocopherol: role of tocopherol-binding proteins. Food and Chemical Toxicology, 37:967-971.
[5] Hickman, K.C.D., Weisler, L., 1949. Vitamin E Preparation. US 2,486,540.
[6] Kamal-Eldin, A., Appelqvist, L., 1996. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids, 31(7):671-701.
[7] Lechtken, P., Hoercher, U., Jessel, B., 1990. Preparation of D-α-Tocopherol from Natural Intermediates. US 4,925,960.
[8] Müller, R.K., Schneider, H., 2000. Aminomethylation of Tocopherols. US 6,066,731.
[9] Weisler, L., Chechak, A.J., 1949. Simultaneous Haloalkylation and Reduction of Organic Compounds. US 2,486,542.
Open peer comments: Debate/Discuss/Question/Opinion
<1>
Guo shijie<502756311@qq.com>
2015-03-21 15:28:59
Please help me finish this task
Pooja@No address<pooja@matrixuniversal.com>
2013-06-19 13:07:42
Dear Sir
I would like to have full content of this article.
Kindly let me know the relevant details.
Kunal S.@No address<kunalsikchi@gmail.com>
2013-06-19 12:48:09
I am a student working on Tocopherols and its derivatives. WOuld be glad to recieve this patent to study the same. Thank you.
Anonymous@No address<No mail>
2011-10-13 10:03:35
good artical