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Received: 2003-02-27

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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.2 P.222-225

http://doi.org/10.1631/jzus.2004.0222


Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays


Author(s):  SHEN Qian-yun, ZHENG Shu-sen

Affiliation(s):  Department of Surgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   shenqianyunhz@yahoo.com.hk

Key Words:  1, 25-dihydroxyvitamin D3, Dendritic cells, Gene expression, cDNA array


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SHEN Qian-yun, ZHENG Shu-sen. Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays[J]. Journal of Zhejiang University Science A, 2004, 5(2): 222-225.

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%A ZHENG Shu-sen
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Abstract: 
In order to study the molecular mechanism of the inhibitory effect of 1,25-dihydroxyvitamin D3 on dendritic cells, experiments were performed using Atlas cDNA expression arrays from Clonetech to identify the differentially expressed genes of dendritic cells by 1,25-dihydroxyvitamin D3. Analysis of cDNA arrays revealed changes in the expression of 9 genes, including those involved in DNA binding and transcription, extracellular cell signaling and communication, intracellular transducers, as well as cell adhesions. The results indicated that a multiple molecular network is involved in the inhibitory role of 1,25-dihydroxyvitamin D3 on dendritic cells. The Atlas Array technology may facilitate the elucidation of complex pharmacological process of 1,25-dihydroxyvitamin D3 on dendritic cells.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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