CLC number: TP391.72
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 5
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SHEN Qian-yun, ZHENG Shu-sen. Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays[J]. Journal of Zhejiang University Science A, 2004, 5(2): 222-225.
@article{title="Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays",
author="SHEN Qian-yun, ZHENG Shu-sen",
journal="Journal of Zhejiang University Science A",
volume="5",
number="2",
pages="222-225",
year="2004",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.0222"
}
%0 Journal Article
%T Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays
%A SHEN Qian-yun
%A ZHENG Shu-sen
%J Journal of Zhejiang University SCIENCE A
%V 5
%N 2
%P 222-225
%@ 1869-1951
%D 2004
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.0222
TY - JOUR
T1 - Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays
A1 - SHEN Qian-yun
A1 - ZHENG Shu-sen
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 2
SP - 222
EP - 225
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2004.0222
Abstract: In order to study the molecular mechanism of the inhibitory effect of 1,25-dihydroxyvitamin D3 on dendritic cells, experiments were performed using Atlas cDNA expression arrays from Clonetech to identify the differentially expressed genes of dendritic cells by 1,25-dihydroxyvitamin D3. Analysis of cDNA arrays revealed changes in the expression of 9 genes, including those involved in DNA binding and transcription, extracellular cell signaling and communication, intracellular transducers, as well as cell adhesions. The results indicated that a multiple molecular network is involved in the inhibitory role of 1,25-dihydroxyvitamin D3 on dendritic cells. The Atlas Array technology may facilitate the elucidation of complex pharmacological process of 1,25-dihydroxyvitamin D3 on dendritic cells.
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