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Design and fabrication of biomimetic four-region drug-laden cartilage scaffolds with porous hollow fibers
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Yu CHEN1,2, Yuzhe MA1,2, Jianzhong FU1,2, Xinhua YAO1,2. Design and fabrication of biomimetic four-region drug-laden cartilage scaffolds with porous hollow fibers[J]. Journal of Zhejiang University Science A, 1998, -1(-1): .
@article{title="Design and fabrication of biomimetic four-region drug-laden cartilage scaffolds with porous hollow fibers",
author="Yu CHEN1,2, Yuzhe MA1,2, Jianzhong FU1,2, Xinhua YAO1,2",
journal="Journal of Zhejiang University Science A",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.A2400513"
}
%0 Journal Article
%T Design and fabrication of biomimetic four-region drug-laden cartilage scaffolds with porous hollow fibers
%A Yu CHEN1
%A 2
%A Yuzhe MA1
%A 2
%A Jianzhong FU1
%A 2
%A Xinhua YAO1
%A 2
%J Journal of Zhejiang University SCIENCE A
%V -1
%N -1
%P
%@ 1673-565X
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.A2400513
TY - JOUR
T1 - Design and fabrication of biomimetic four-region drug-laden cartilage scaffolds with porous hollow fibers
A1 - Yu CHEN1
A1 - 2
A1 - Yuzhe MA1
A1 - 2
A1 - Jianzhong FU1
A1 - 2
A1 - Xinhua YAO1
A1 - 2
J0 - Journal of Zhejiang University Science A
VL - -1
IS - -1
SP -
EP -
%@ 1673-565X
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.A2400513
Abstract: Articular cartilage, which plays a vital role in joint structure, is susceptible to damage from trauma and degenerative joint diseases. Traditional methods for cartilage treatment often involve complex surgical procedures with limited efficacy. Alternatively, implantable drug-loaded scaffolds are an increasingly attractive cartilage treatment option. To address the challenges of structural and functional compatibility between scaffolds and native cartilage, as well as issues related to drug loading, we design a novel cartilage scaffold with a four-region hollow porous fiber network structure. Using an extrusion-based 3D printing platform, a biphasic silicone ink composed primarily of liquid-phase silicone and solid particles was employed to construct the hollow porous fiber network. Mechanical compression tests demonstrate that the cartilage scaffold has mechanical characteristics similar to those of native cartilage tissue, and ultraviolet spectrophotometry measurements confirm its ability to control drug release. These results showcase the feasibility and effectiveness of the proposed cartilage substitute structure.
Open peer comments: Debate/Discuss/Question/Opinion
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