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On-line Access: 2021-02-01
Received: 2020-07-24
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Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds
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Yanen Wang, Ying Guo, Qinghua Wei, Xinpei Li, Kang Ji & Kun Zhang . Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds[J]. Journal of Zhejiang University Science D, 2021, 4(3): 541-567.
@article{title="Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds",
author="Yanen Wang, Ying Guo, Qinghua Wei, Xinpei Li, Kang Ji & Kun Zhang ",
journal="Journal of Zhejiang University Science D",
volume="4",
number="3",
pages="541-567",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00119-y"
}
%0 Journal Article
%T Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds
%A Yanen Wang
%A Ying Guo
%A Qinghua Wei
%A Xinpei Li
%A Kang Ji & Kun Zhang
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 3
%P 541-567
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-020-00119-y
TY - JOUR
T1 - Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds
A1 - Yanen Wang
A1 - Ying Guo
A1 - Qinghua Wei
A1 - Xinpei Li
A1 - Kang Ji & Kun Zhang
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 3
SP - 541
EP - 567
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-020-00119-y
Abstract: Currently, osteochondral (OC) tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage. However, it is still challenging to ensure the integrity, physiological function and regeneration ability of stratified OC scaffolds in clinical application. Biomimetic OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC tissue. As a consequence, the researches on biomimetic design to achieve the tissue function of each layer, and additive manufacture (AM) to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable progress. In this review, the design methods of biomaterial and structure as well as computer-aided design, and performance prediction of biopolymer-based OC scaffolds are presented; then, the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized; finally, the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds.
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