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Bio-Design and Manufacturing  2021 Vol.4 No.3 P.541-567

http://doi.org/10.1007/s42242-020-00119-y


Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds


Author(s):  Yanen Wang, Ying Guo, Qinghua Wei, Xinpei Li, Kang Ji & Kun Zhang

Affiliation(s):  Department of Mechanical and Electronic Engineering, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, China; more

Corresponding email(s):   wangyanen@nwpu.edu.cn

Key Words:  Osteochondral tissue, Biomimetic scaffold, Additive manufacture, Integrated manufacture


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Yanen Wang, Ying Guo, Qinghua Wei, Xinpei Li, Kang Ji & Kun Zhang . Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds[J]. Journal of Zhejiang University Science D, 2021, 4(3): 541-567.

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Abstract: 
Currently, osteochondral (OC) tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage. However, it is still challenging to ensure the integrity, physiological function and regeneration ability of stratified OC scaffolds in clinical application. Biomimetic OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC tissue. As a consequence, the researches on biomimetic design to achieve the tissue function of each layer, and additive manufacture (AM) to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable progress. In this review, the design methods of biomaterial and structure as well as computer-aided design, and performance prediction of biopolymer-based OC scaffolds are presented; then, the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized; finally, the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds.

西北工业大学汪焰恩等 | 生物聚合物基骨软骨仿生支架的设计与制造研究现状

本综述论文聚焦聚合物基骨软骨支架仿生设计及制造策略。骨软骨组织工程在修复软骨损伤及早期骨关节炎的治疗中具有重要意义。然而,要确保其多层结构的完整性、生理功能和再生能力仍然面临着挑战。本文系统地回顾了不同生物高分子聚合物基骨软骨支架仿生设计和生物增材制造研究现状(包括确保骨软骨支架异质区域结构、梯度界面稳定性等仿生设计方案);讨论了基于Y型微流控、生长因子分层负载、多生物材料共混等生物增材制造技术,及其所制备的骨软骨支架制造策略特点和局限性;介绍了多工艺制造骨软骨组织工程领域的发展及优势,并给出所制备的骨软骨支架性能评估方法和目标。文章也展望了新型生物材料的制备技术及多功能生物增材制造仿生骨软骨的研究趋势。

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