Effect of vitamin B12 on cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice
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Shu-fan Zhao, Mao-zhou Chai, Min Wu, Yong-hong He, Tian Meng, Bing Shi. Effect of vitamin B12 on cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice[J]. Journal of Zhejiang University Science B, 2014, 15(3): 289-294.
@article{title="Effect of vitamin B12 on cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice",
author="Shu-fan Zhao, Mao-zhou Chai, Min Wu, Yong-hong He, Tian Meng, Bing Shi",
journal="Journal of Zhejiang University Science B",
volume="15",
number="3",
pages="289-294",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1300083"
}
%0 Journal Article
%T Effect of vitamin B12 on cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice
%A Shu-fan Zhao
%A Mao-zhou Chai
%A Min Wu
%A Yong-hong He
%A Tian Meng
%A Bing Shi
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 3
%P 289-294
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300083
TY - JOUR
T1 - Effect of vitamin B12 on cleft palate induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice
A1 - Shu-fan Zhao
A1 - Mao-zhou Chai
A1 - Min Wu
A1 - Yong-hong He
A1 - Tian Meng
A1 - Bing Shi
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 3
SP - 289
EP - 294
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300083
Abstract: The purpose of this study was to investigate the effect of vitamin B12 on palatal development by co-administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dexamethasone (DEX). We examined the morphological and histological features of the palatal shelf and expression levels of key signaling molecules (transforming growth factor-β3 (TGF-β3) and TGF-β type I receptor (activin receptor-like kinase 5, ALK5)) during palatogenesis among a control group (Group A), TCDD+DEX exposed group (Group B), and TCDD+DEX+vitamin B12 exposed group (Group C). While we failed to find that vitamin B12 decreased the incidence of cleft palate induced by TCDD+DEX treatment, the expression levels of key signaling molecules (TGF-β3 and ALK5) during palatogenesis were significantly modulated. In TCDD+DEX exposed and TCDD+DEX+vitamin B12 exposed groups, palatal shelves could not contact in the midline due to their small sizes. Our results suggest that vitamin B12 may inhibit the expression of some cleft palate inducers such as TGF-β3 and ALK5 in DEX+TCDD exposed mice, which may be beneficial against palatogenesis to some degree, even though we were unable to observe a protective role of vitamin B12 in morphological and histological alterations of palatal shelves induced by DEX and TCDD.
Full Text:
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Summary: 
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CLC number: R780.1
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2014-02-11
Cited: 3
Clicked: 11581
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