CLC number: R541.7+5
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2014-09-24
Cited: 5
Clicked: 7771
Hui Cheng, Yin-yin Dai, Ru-hong Jiang, Qiang Liu, Ya-xun Sun, Jian-wei Lin, Zu-wen Zhang, Shi-quan Chen, Jun Zhu, Xia Sheng, Chen-yang Jiang. Non-pulmonary vein foci induced before and after pulmonary vein isolation in patients undergoing ablation therapy for paroxysmal atrial fibrillation: incidence and clinical outcome[J]. Journal of Zhejiang University Science B, 2014, 15(10): 915-922.
@article{title="Non-pulmonary vein foci induced before and after pulmonary vein isolation in patients undergoing ablation therapy for paroxysmal atrial fibrillation: incidence and clinical outcome",
author="Hui Cheng, Yin-yin Dai, Ru-hong Jiang, Qiang Liu, Ya-xun Sun, Jian-wei Lin, Zu-wen Zhang, Shi-quan Chen, Jun Zhu, Xia Sheng, Chen-yang Jiang",
journal="Journal of Zhejiang University Science B",
volume="15",
number="10",
pages="915-922",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400146"
}
%0 Journal Article
%T Non-pulmonary vein foci induced before and after pulmonary vein isolation in patients undergoing ablation therapy for paroxysmal atrial fibrillation: incidence and clinical outcome
%A Hui Cheng
%A Yin-yin Dai
%A Ru-hong Jiang
%A Qiang Liu
%A Ya-xun Sun
%A Jian-wei Lin
%A Zu-wen Zhang
%A Shi-quan Chen
%A Jun Zhu
%A Xia Sheng
%A Chen-yang Jiang
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 10
%P 915-922
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400146
TY - JOUR
T1 - Non-pulmonary vein foci induced before and after pulmonary vein isolation in patients undergoing ablation therapy for paroxysmal atrial fibrillation: incidence and clinical outcome
A1 - Hui Cheng
A1 - Yin-yin Dai
A1 - Ru-hong Jiang
A1 - Qiang Liu
A1 - Ya-xun Sun
A1 - Jian-wei Lin
A1 - Zu-wen Zhang
A1 - Shi-quan Chen
A1 - Jun Zhu
A1 - Xia Sheng
A1 - Chen-yang Jiang
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 10
SP - 915
EP - 922
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400146
Abstract: Objective: To evaluate the incidence and clinical outcome of adenosine triphosphate (ATP) plus isoproterenol (ISP)-induced non-pulmonary vein (PV) foci before and after circumferential PV isolation (CPVI) during index ablation in patients with paroxysmal atrial fibrillation (PAF). Methods: In 80 consecutive patients undergoing catheter ablation for drug-refractory, symptomatic PAF at our hospital from April 2010 to January 2011, atrial fibrillation (AF) was provoked with ATP (20 mg) and ISP (20 μg/min) administration before and after CPVI. The spontaneous initiation of AF was mapped and recorded. Results: Before ablation, AF mostly originating from PVs (PV vs. non-PV, 36/70 vs. 3/70; P<0.01) was induced in 39 patients with sinus rhythm. CPVI significantly suppressed AF inducibility; however, more non-PV foci were provoked (post-CPVI vs. pre-CPVI, 13/76 vs. 3/70; P=0.016). Patients with pre- and post-CPVI induced AF (n=49) were divided according to non-PV foci being induced (group N, n=17) or not (group P, n=32). After mean (19.2±8.2) months follow-up, 88.2% (15/17) and 65.6% (21/32) of patients in groups N and P, respectively, were free from AF recurrence (P=0.088). Conclusions: ATP+ISP administration effectively provokes non-PV foci, especially after CPVI in PAF patients. Although in this study difference did not achieve statistical significance, supplementary ablation targeting non-PV foci might benefit clinical outcome.
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