CLC number: R714.21
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2016-02-15
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Yun-lei Cao, Zhao-feng Zhang, Jian Wang, Mao-hua Miao, Jian-hua Xu, Yue-ping Shen, Ai-min Chen, Jing Du, Wei Yuan. Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss[J]. Journal of Zhejiang University Science B, 2016, 17(3): 218-224.
@article{title="Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss",
author="Yun-lei Cao, Zhao-feng Zhang, Jian Wang, Mao-hua Miao, Jian-hua Xu, Yue-ping Shen, Ai-min Chen, Jing Du, Wei Yuan",
journal="Journal of Zhejiang University Science B",
volume="17",
number="3",
pages="218-224",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500180"
}
%0 Journal Article
%T Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss
%A Yun-lei Cao
%A Zhao-feng Zhang
%A Jian Wang
%A Mao-hua Miao
%A Jian-hua Xu
%A Yue-ping Shen
%A Ai-min Chen
%A Jing Du
%A Wei Yuan
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 3
%P 218-224
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500180
TY - JOUR
T1 - Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss
A1 - Yun-lei Cao
A1 - Zhao-feng Zhang
A1 - Jian Wang
A1 - Mao-hua Miao
A1 - Jian-hua Xu
A1 - Yue-ping Shen
A1 - Ai-min Chen
A1 - Jing Du
A1 - Wei Yuan
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 3
SP - 218
EP - 224
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500180
Abstract: recurrent pregnancy loss (RPL) is a condition with complex etiologies, to which both genetic and environmental factors may contribute. During the last decade, studies indicated that the expression patterns of the prokineticin receptor (PKR1 and PKR2) are closely related to early pregnancy. However, there are few studies on the role of PKR1 and PKR2 in RPL. In this study, we purpose to investigate the association between polymorphisms of the prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and RPL on a group of 93 RPL cases and 169 healthy controls. Genotyping of the single nucleotide polymorphisms (SNPs) was performed using a Sequenom MassARRAY iPLEX system. The results revealed a significant association between PKR2 rs6053283 polymorphism and RPL (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.
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