CLC number: R714.21
On-line Access: 2016-03-07
Received: 2015-07-25
Revision Accepted: 2015-12-03
Crosschecked: 2016-02-15
Cited: 0
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Yun-lei Cao, Zhao-feng Zhang, Jian Wang, Mao-hua Miao, Jian-hua Xu, Yue-ping Shen, Ai-min Chen, Jing Du, Wei Yuan. Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss[J]. Journal of Zhejiang University Science B, 2016, 17(3): 218-224.
@article{title="Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss",
author="Yun-lei Cao, Zhao-feng Zhang, Jian Wang, Mao-hua Miao, Jian-hua Xu, Yue-ping Shen, Ai-min Chen, Jing Du, Wei Yuan",
journal="Journal of Zhejiang University Science B",
volume="17",
number="3",
pages="218-224",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500180"
}
%0 Journal Article
%T Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss
%A Yun-lei Cao
%A Zhao-feng Zhang
%A Jian Wang
%A Mao-hua Miao
%A Jian-hua Xu
%A Yue-ping Shen
%A Ai-min Chen
%A Jing Du
%A Wei Yuan
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 3
%P 218-224
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500180
TY - JOUR
T1 - Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss
A1 - Yun-lei Cao
A1 - Zhao-feng Zhang
A1 - Jian Wang
A1 - Mao-hua Miao
A1 - Jian-hua Xu
A1 - Yue-ping Shen
A1 - Ai-min Chen
A1 - Jing Du
A1 - Wei Yuan
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 3
SP - 218
EP - 224
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500180
Abstract: recurrent pregnancy loss (RPL) is a condition with complex etiologies, to which both genetic and environmental factors may contribute. During the last decade, studies indicated that the expression patterns of the prokineticin receptor (PKR1 and PKR2) are closely related to early pregnancy. However, there are few studies on the role of PKR1 and PKR2 in RPL. In this study, we purpose to investigate the association between polymorphisms of the prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and RPL on a group of 93 RPL cases and 169 healthy controls. Genotyping of the single nucleotide polymorphisms (SNPs) was performed using a Sequenom MassARRAY iPLEX system. The results revealed a significant association between PKR2 rs6053283 polymorphism and RPL (P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.
[1]Battersby, S., Critchley, H.O., Morgan, K., et al., 2004. Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle. J. Clin. Endocrinol. Metab., 89(5):2463-2469.
[2]Chen, J., Kuei, C., Sutton, S., et al., 2005. Identification and pharmacological characterization of prokineticin 2β as a selective ligand for prokineticin receptor 1. Mol. Pharmacol., 67(6):2070-2076.
[3]Cheng, M.Y., Bullock, C.M., Li, C., et al., 2002. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature, 417(6887):405-410.
[4]Denison, F.C., Battersby, S., King, A.E., et al., 2008. Prokineticin-1: a novel mediator of the inflammatory response in third-trimester human placenta. Endocrinology, 149(7):3470-3477.
[5]Dorsch, M., Qiu, Y., Soler, D., et al., 2005. PK1/EG-VEGF induces monocyte differentiation and activation. J. Leukoc. Biol., 78(2):426-434.
[6]Evans, J., Catalano, R.D., Morgan, K., et al., 2008. Prokineticin 1 signaling and gene regulation in early human pregnancy. Endocrinology, 149(6):2877-2887.
[7]Evans, J., Catalano, R.D., Brown, P., et al., 2009. Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor. FASEB J., 23(7):2165-2175.
[8]Ferrara, N., Frantz, G., Le Couter, J., et al., 2003. Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries. Am. J. Pathol., 162(6):1881-1893.
[9]Gabriel, S., Ziaugra, L., Tabbaa, D., 2009. SNP genotyping using the Sequenom MassARRAY iPLEX platform. Curr. Protoc. Hum. Genet., 60:2.12.1-2.12.18.
[10]Haouzi, D., Mahmoud, K., Fourar, M., et al., 2009. Identification of new biomarkers of human endometrial receptivity in the natural cycle. Hum. Reprod., 24(1):198-205.
[11]Hoffmann, P., Feige, J.J., Alfaidy, N., 2006. Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy. Endocrinology, 147(4):1675-1684.
[12]Le Couter, J., Kowalski, J., Foster, J., et al., 2001. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature, 412(6850):877-884.
[13]Le Couter, J., Lin, R., Ferrara, N., 2002. Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis. Nat. Med., 8(9):913-917.
[14]Le Couter, J., Lin, R., Tejada, M., et al., 2003. The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: localization of Bv8 receptors to endothelial cells. PNAS, 100(5):2685-2690.
[15]Le Couter, J., Zlot, C., Tejada, M., et al., 2004. Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization. PNAS, 101(48):16813-16818.
[16]Lee, H.H., Hong, S.H., Shin, S.J., et al., 2010. Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion. Fertil. Steril., 93(4):1244-1247.
[17]Li, M., Bullock, C.M., Knauer, D.J., et al., 2001. Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle. Mol. Pharmacol., 59(4):692-698.
[18]Li, T.C., Makris, M., Tomsu, M., et al., 2002. Recurrent miscarriage: aetiology, management and prognosis. Hum. Reprod. Update, 8(5):463-481.
[19]Lim, H., Paria, B.C., Das, S.K., et al., 1997. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell, 91(2):197-208.
[20]Lin, D.C., Bullock, C.M., Ehlert, F.J., et al., 2002. Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. J. Biol. Chem., 277(22):19276-19280.
[21]Long, J.C., Caceres, J.F., 2009. The SR protein family of splicing factors: master regulators of gene expression. Biochem. J., 417(1):15-27.
[22]Monnier, C., Dode, C., Fabre, L., et al., 2009. PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Hum. Mol. Genet., 18(1):75-81.
[23]Morton, A.J., Wood, N.I., Hastings, M.H., et al., 2005. Disintegration of the sleep-wake cycle and circadian timing in Huntington’s disease. J. Neurosci., 25(1):157-163.
[24]O'Callaghan, M.E., MacLennan, A.H., Gibson, C.S., et al., 2012. Fetal and maternal candidate single nucleotide polymorphism associations with cerebral palsy: a case-control study. Pediatrics, 129(2):e414-e423.
[25]Practice Committee of the American Society for Reproductive Medicine, 2013. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil. Steril., 99(1):63.
[26]Robb, L., Li, R., Hartley, L., et al., 1998. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nat. Med., 4(3):303-308.
[27]Sarfati, J., Guiochon-Mantel, A., Rondard, P., et al., 2010. A comparative phenotypic study of Kallmann syndrome patients carrying monoallelic and biallelic mutations in the prokineticin 2 or prokineticin receptor 2 genes. J. Clin. Endocrinol. Metab., 95(2):659-669.
[28]Schweitz, H., Pacaud, P., Diochot, S., et al., 1999. MIT1, a black mamba toxin with a new and highly potent activity on intestinal contraction. FEBS Lett., 461(3):183-188.
[29]Shaw, J.L., Denison, F.C., Evans, J., et al., 2010. Evidence of prokineticin dysregulation in fallopian tube from women with ectopic pregnancy. Fertil. Steril., 94(5):1601-1608.
[30]Shi, Y.Y., He, L., 2005. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res., 15(2):97-98.
[31]Smith, P.J., Zhang, C., Wang, J., et al., 2006. An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers. Hum. Mol. Genet., 15(16):2490-2508.
[32]Soga, T., Matsumoto, S., Oda, T., et al., 2002. Molecular cloning and characterization of prokineticin receptors. Biochim. Biophys. Acta, 1579(2-3):173-179.
[33]Stewart, C.L., Kaspar, P., Brunet, L.J., et al., 1992. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature, 359(6390):76-79.
[34]Su, M.T., Lin, S.H., Lee, I.W., 2010. Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss. Hum. Reprod., 25(11):2923-2930.
[35]Tabibzadeh, S., Kong, Q.F., Babaknia, A., et al., 1995. Progressive rise in the expression of interleukin-6 in human endometrium during menstrual cycle is initiated during the implantation window. Hum. Reprod., 10(10):2793-2799.
[36]Tiberi, F., Tropea, A., Apa, R., et al., 2010. Prokineticin 1 mRNA expression in the endometrium of healthy women and in the eutopic endometrium of women with endometriosis. Fertil. Steril., 93(7):2145-2149.
[37]Wechselberger, C., Puglisi, R., Engel, E., et al., 1999. The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. FEBS Lett., 462(1-2):177-181.
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