CLC number: R574
On-line Access: 2016-03-07
Received: 2015-10-11
Revision Accepted: 2015-12-09
Crosschecked: 2016-02-15
Cited: 1
Clicked: 4391
Xi Chen, Xi-shuang Liu. Hydrogen sulfide from a NaHS source attenuates dextran sulfate sodium (DSS)-induced inflammation via inhibiting nuclear factor-κB[J]. Journal of Zhejiang University Science B, 2016, 17(3): 209-217.
@article{title="Hydrogen sulfide from a NaHS source attenuates dextran sulfate sodium (DSS)-induced inflammation via inhibiting nuclear factor-κB",
author="Xi Chen, Xi-shuang Liu",
journal="Journal of Zhejiang University Science B",
volume="17",
number="3",
pages="209-217",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500248"
}
%0 Journal Article
%T Hydrogen sulfide from a NaHS source attenuates dextran sulfate sodium (DSS)-induced inflammation via inhibiting nuclear factor-κB
%A Xi Chen
%A Xi-shuang Liu
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 3
%P 209-217
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500248
TY - JOUR
T1 - Hydrogen sulfide from a NaHS source attenuates dextran sulfate sodium (DSS)-induced inflammation via inhibiting nuclear factor-κB
A1 - Xi Chen
A1 - Xi-shuang Liu
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 3
SP - 209
EP - 217
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500248
Abstract: This study investigated the alleviating effects of hydrogen sulfide (H2S), derived from sodium hydrosulfide (NaHS), on inflammation induced by dextran sulfate sodium (DSS) in both in vivo and in vitro models. We found that NaHS injection markedly decreased rectal bleeding, diarrhea, and histological injury in DSS-challenged mice. NaHS (20 μmol/L) reversed DSS-induced inhibition in cell viability in Caco-2 cells and alleviated pro-inflammation cytokine expression in vivo and in vitro, indicating an anti-inflammatory function for H2S. It was also found that H2S may regulate cytokine expression by inhibiting the nuclear factor-κ;b (NF-κ;b) signaling pathway. In conclusion, our results demonstrated that H2S alleviated DSS-induced inflammation in vivo and in vitro and that the signal mechanism might be associated with the NF-κB signaling pathway.
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