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Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant long noncoding RNAs
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Shimaa O. ALI, Nancy N. SHAHIN, Marwa M. SAFAR, Sherine M. RIZK. Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant long noncoding RNAs[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant long noncoding RNAs",
author="Shimaa O. ALI, Nancy N. SHAHIN, Marwa M. SAFAR, Sherine M. RIZK",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400242"
}
%0 Journal Article
%T Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant long noncoding RNAs
%A Shimaa O. ALI
%A Nancy N. SHAHIN
%A Marwa M. SAFAR
%A Sherine M. RIZK
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400242
TY - JOUR
T1 - Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant long noncoding RNAs
A1 - Shimaa O. ALI
A1 - Nancy N. SHAHIN
A1 - Marwa M. SAFAR
A1 - Sherine M. RIZK
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400242
Abstract: Objective: The use of stem cells is a promising strategy for seizure treatment owing to their unique characteristics. We investigated the role of endothelial progenitor cells (EPCs) in a pentylenetetrazole (PTZ)-induced rat seizure model. A selected panel of long noncoding RNAs (lncRNAs), which maintain an elaborate balance in brain neural regulatory networks as well as the autophagy pathway, was also targeted. Methods: The impact of intravenously administered EPCs on PTZ-kindling in rats was evaluated by measuring neuronal damage markers, neurotrophic factors, and relevant lncRNA gene expressions. Rat behavior was assessed using Y-maze and open field (OFT) tests. Results: EPCs mitigated seizure-associated neurological damage and reversed the PTZ-induced working memory and locomotor activity deficits, as evidenced by improved performance in the Y-maze and OFT tests. EPCs treatment reversed downregulation of the expression of the lncRNAs Evf2, Pnky, Dlx1, APF, HOTAIR, and FLJ11812. EPCs also boosted vascular endothelial growth factor (VEGF) expression. The ameliorative effect achieved by EPCs was comparable to that produced by valproate. Conclusions: These findings indicate that EPCs ameliorate kindling epileptic seizures and their associated abnormalities and that the effect of EPCs may be mediated via the upregulation of certain regulatory lncRNAs.
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