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The Nrf2 signaling pathway and its molecular regulatory mechanism
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Yunfei PAN1, Xiaodong ZHANG2, Yimin LU2, Hao QIN2, Rong CHEN1, Handong FAN2. The Nrf2 signaling pathway and its molecular regulatory mechanism[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="The Nrf2 signaling pathway and its molecular regulatory mechanism",
author="Yunfei PAN1, Xiaodong ZHANG2, Yimin LU2, Hao QIN2, Rong CHEN1, Handong FAN2",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500053"
}
%0 Journal Article
%T The Nrf2 signaling pathway and its molecular regulatory mechanism
%A Yunfei PAN1
%A Xiaodong ZHANG2
%A Yimin LU2
%A Hao QIN2
%A Rong CHEN1
%A Handong FAN2
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
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%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500053
TY - JOUR
T1 - The Nrf2 signaling pathway and its molecular regulatory mechanism
A1 - Yunfei PAN1
A1 - Xiaodong ZHANG2
A1 - Yimin LU2
A1 - Hao QIN2
A1 - Rong CHEN1
A1 - Handong FAN2
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2500053
Abstract: nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial transcription factor that orchestrates the expression of genes involved in antioxidant defense, detoxification, and the maintenance of cellular homeostasis. This review provides a comprehensive analysis of the dual regulatory role of Nrf2 in both normal physiological and pathological conditions, focusing on the molecular mechanisms by which it modulates mitochondrial function, oxidative stress, inflammation, and autophagy. The review summarizes the current knowledge on the effects of various synthetic and natural compounds, such as flavonoids and resveratrol, on Nrf2 activity. The review also explores the therapeutic potential of Nrf2 in neurodegenerative diseases, cancer, diabetes, and other disorders, laying a foundation for the development of Nrf2-targeted pharmacological interventions.
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