Cognitive function among COVID-19 survivors in subacute phase during epidemic of Omicron variant in China
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Xue LUO1,2*, Shufei ZENG1,2*, Shuai LIU1,2*, Yuanhui LI3, Leqin FANG1,2, Dai LI3, Qianqian XIN1,2, Shixu DU1,2, Yan XU1,2, Bin ZHANG1,2. Cognitive function among COVID-19 survivors in subacute phase during epidemic of Omicron variant in China[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Cognitive function among COVID-19 survivors in subacute phase during epidemic of Omicron variant in China",
author="Xue LUO1,2*, Shufei ZENG1,2*, Shuai LIU1,2*, Yuanhui LI3, Leqin FANG1,2, Dai LI3, Qianqian XIN1,2, Shixu DU1,2, Yan XU1,2, Bin ZHANG1,2",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500553"
}
%0 Journal Article
%T Cognitive function among COVID-19 survivors in subacute phase during epidemic of Omicron variant in China
%A Xue LUO1
%A 2*
%A Shufei ZENG1
%A 2*
%A Shuai LIU1
%A 2*
%A Yuanhui LI3
%A Leqin FANG1
%A 2
%A Dai LI3
%A Qianqian XIN1
%A 2
%A Shixu DU1
%A 2
%A Yan XU1
%A 2
%A Bin ZHANG1
%A 2
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500553
TY - JOUR
T1 - Cognitive function among COVID-19 survivors in subacute phase during epidemic of Omicron variant in China
A1 - Xue LUO1
A1 - 2*
A1 - Shufei ZENG1
A1 - 2*
A1 - Shuai LIU1
A1 - 2*
A1 - Yuanhui LI3
A1 - Leqin FANG1
A1 - 2
A1 - Dai LI3
A1 - Qianqian XIN1
A1 - 2
A1 - Shixu DU1
A1 - 2
A1 - Yan XU1
A1 - 2
A1 - Bin ZHANG1
A1 - 2
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP - 0
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500553
Abstract: Following the relaxation of pandemic control measures in China, the impact of coronavirus disease 2019 (COVID-19) on cognitive function in the Chinese population has not been investigated. Therefore, this study aimed to assess cognitive function and identify its risk factors in the subacute phase (<3 months) of COVID-19 patients during the epidemic wave of the omicron variant. In this nationwide smartphone-based online assessment from January 15 to 29, 2023, the Integrated Cognitive Assessment (ICA) and the Number Ordering Test (NOT) were used to assess cognitive function. Among the 9,663 participants, 8,905 (92.2%) were COVID-19 survivors. These patients performed poorly in most neuropsychological results (p<0.05), but only the ICA accuracies were lower, controlling for socio-demographics (p<0.05, partial η2≰0.001). After the initial recovery, 5,832 (65.5%) COVID-19 survivors reported inflexible thinking, 5,419 (60.9%) noted slowed information processing speed, and 4,344 (48.8%) reported insomnia. Being a female, older age, low education level, living in Northwest China, and insomnia were significantly associated with poor performance in the key neuropsychological results (range, absolute value of β 0.023-0.430, p<0.05). In the subacute phase of COVID-19, subjective cognitive complaints were highly prevalent, whereas objective cognitive differences were subtle. Despite the mild overall impact, vulnerable subgroups-such as females, older adults, low education level and patients with insomnia-showed greater susceptibility to these cognitive changes.
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Received: 2025-10-23
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